Colorado - Significance region: Local
| Shannon Farm |
| Shawnee |
| Sheedy Mansion |
| Sheely Bridge |
| Sherman and Ross Block Building |
| Sherman Street Historic District |
| Sherman Street Historic Residential District |
| Shilling-Lamb House |
| Shirley Hotel |
| Shrine of the Sun |
| """Sierras y Colores"" Mural" |
| Silesca Ranger Station |
| Sixth Avenue Community Church |
| Slate Creek Bridge |
| Smiley Junior High School |
| Smith, Edwin L. Building |
| Smith-Elisha House |
| Smith-Friskey Ranch |
| Smith, Milo A., House |
| Smith, Pierce T., House |
| Smith, William, House |
| Snogo Snow Plow |
| Soda Creek Ranch |
| Solomon Batterson Ranch (Rural Historic Landscape) |
| Sound Democrat Mill and Mine and Silver Queen Mine |
| South Canon Bridge |
| South Canon High School |
| Southern Hotel |
| South High School |
| South Park City Museum |
| South Park Community Church |
| South Park Lager Beer Brewery |
| South Platte River Bridge |
| South Platte River Bridges |
| South Ranch |
| South Side-Baker Historic District |
| Spratlen-Anderson Wholesale Grocery Company-Davis Brothers Warehouse |
| Spring Creek Archeological District |
| Spring Creek Bridge |
| Springfield Schoolhouse |
| Spring House-Moynahan House |
| Spring Valley School |
| Spruce Lodge |
| Squires-Tourtellot House |
| St. Andrews Episcopal Church |
| Stanley School-Montclair School |
| St. Anthony's Roman Catholic Church |
| Starbuck Park |
| Star Filling Station |
| Star Journal Model Home |
| Starkville Central School |
| Starr Manor |
| State Armory |
| Staunton Ranch Rural Historic Landscape |
| St. Charles Bridge |
| St. Charles River Bridge |
| St. Dominic's Church |
| Steamboat Apartments |
| Steamboat Laundry Building |
| Steamboat Springs Depot |
| Steamboat Springs Downtown Historic District |
| Stearns House |
| St. Elizabeth's Church |
| St. Elizabeth's Retreat Chapel |
| Sterling Public Library |
| Sterling Union Pacific Railroad Depot |
| Stickney, Charles H., House |
| St. Ignatius Loyola Church |
| St. John's Greek Orthodox Church |
| St. Joseph's Church |
| St. Joseph's Polish Roman Catholic Church |
| St. Joseph's Roman Catholic Church of Denver |
| St. Mark's Parish Church |
| St. Mark United Presbyterian Church |
| St. Mary's Catholic Church |
| Stockbridge House |
| Stocke-Walter Addition Historic District |
| Stolmes House |
| Stolte House |
| Stone House |
| Stonemen's Row Historic District |
| Stonington First Methodist-Episcopal Church |
| St. Patrick Mission Church |
| St. Paul African Methodist Episcopal (AME) Church |
| St. Paul's Church |
| St. Paul's English Evangelical Lutheran Church |
| Stranges Grocery |
| Streit, J. L., House |
| St. Stephen's Episcopal Church, 1881 |
| St. Stephen's Lutheran Church |
| St. Thomas Episcopal Church |
| Sumers Lodge |
| Summer Saloon |
| Summit Creek Ranger Station |
| Summit Lake Park |
| Sunshine School |
| Superintendent's Residence, Great Sand Dunes National Monument |
| Surface Creek Livestock Company Silos |
| Sutherland Bridge |
| Swanson, Gustav and Annie, Farm |
Data from United States Park Service and Wikidata
