Wyoming - Significance region: National
| Agate Basin Site |
| Allen, Garrett, Prehistoric Site |
| Ames Monument |
| Ames Monument (NHL) |
| Anderson Lodge |
| Big Goose Creek Buffalo Jump |
| Bridger Antelope Trap |
| Bridger's Pass |
| Buffalo Bill Boyhood Home |
| Buffalo Bill Dam |
| Buffalo Bill Statue |
| Casper Buffalo Trap |
| Castle Gardens Petroglyph Site |
| Cheyenne-Black Hills Stage Route and Rawhide Buttes and Running Water Stage Stations |
| Colter's Hell |
| Connor Battlefield |
| Dead Indian Campsite |
| Expedition Island |
| Father DeSmet's Prairie Mass Site |
| Fort Bonneville |
| Fort Bridger |
| Fort Caspar |
| Fort David A. Russell |
| Fort Fetterman |
| Fort Halleck |
| Fort Laramie National Historic Site |
| Fort Laramie Three-Mile Hog Ranch |
| Fort McKinney |
| Fort Phil Kearny and Associated Sites |
| Fort Reno |
| Fort Steele |
| Fort Washakie Historic District |
| Fort Yellowstone |
| Frewen, Moreton, House |
| Glenrock Buffalo Jump |
| Grand Loop Road Historic District |
| Hanson Site |
| Heart Mountain Relocation Center |
| Horner Site |
| Huckleberry Mountain Fire Lookout |
| Independence Rock |
| Inyan Kara Mountain |
| Irma Hotel |
| Jackson Lake Lodge |
| Lake Fish Hatchery Historic District |
| Lake Guernsey State Park |
| Lake Hotel |
| Legend Rock Petroglyph Site |
| Martin's Cove |
| McKean Archeological Site (48CK7) |
| Medicine Lodge Creek Site |
| Medicine Wheel-Medicine Mountain |
| Menor's Ferry |
| Miller Cabin |
| Murie Ranch Historic District |
| Murie Residence |
| Names Hill |
| Natural Corrals Archeological Site (48SW336) |
| Norris, Madison, and Fishing Bridge Museums |
| North Entrance Road Historic District |
| Obsidian Cliff |
| Old Faithful Historic District |
| Old Faithful Inn |
| Oregon Trail Ruts |
| Pathfinder Dam |
| Pathfinder Dam Historic District |
| Penney, J. C., Historic District |
| Platte River Crossing |
| Powars II Paleoindian Hematite Quarry |
| Register Cliff |
| Reliance Tipple |
| Sheridan Inn |
| Shoshone-Episcopal Mission |
| South Pass |
| Split Rock Prehistoric Site (48FR1484) |
| Split Rock, Twin Peaks |
| Sun, Tom, Ranch |
| Swan Land and Cattle Company Headquarters |
| Teapot Rock |
| Trail End |
| Union Pacific Railroad Complex |
| Union Pacific Railroad Complex |
| Union Pacific Railroad Depot |
| Union Pass |
| Upper Green River Rendezvous Site |
| UXU Ranch |
| Vore Buffalo Jump |
| Wapiti Ranger Station |
| Wyoming State Capitol and Grounds |
Data from United States Park Service and Wikidata
