West Virginia - Significance region: National
| Allstadt House and Ordinary |
| Andrews Methodist Church |
| Arthurdale Historic District |
| Baltimore and Ohio Railroad Martinsburg Shops |
| Barrackville Covered Bridge |
| Beallair |
| Berkeley Springs State Park |
| Bethany Historic District |
| Blair Mountain Battlefield |
| Blennerhassett Island Historic District |
| Buck, Pearl, House |
| Buffalo Indian Village Site |
| Burning Springs Complex |
| Camp Allegheny |
| Campbell, Alexander, Mansion |
| Carnifex Ferry State Park |
| Cedar Lawn |
| Chafin House |
| Cheat Summit Fort |
| Claymont Court |
| Clover Site |
| Cold Spring |
| Davis and Elkins Historic District |
| Delta Tau Delta Founders House |
| East Hall |
| Elkins Coal and Coke Company Historic District |
| Elmwood |
| Fairfax Stone Site |
| Fort Boreman |
| Fort Pleasant |
| Garrison, Memphis Tennessee House |
| Grafton National Cemetery |
| Grave Creek Mound |
| Greenbrier County Courthouse and Lewis Spring |
| Greenbrier, The |
| Hamilton Farm Petroglyphs |
| Harewood |
| Harpers Ferry Historic District |
| Harpers Ferry National Historical Park |
| Harvey House |
| High Level Bridge |
| Indian Cave Petroglyphs |
| Jackson's Mill |
| Jarvis, Anna, House |
| Jefferson County Courthouse |
| Jenkins, Gen. Albert Gallatin, House |
| La Belle Iron Works |
| Lee, Lighthorse Harry, Cabin |
| Lewisburg Historic District |
| Malden Historic District |
| Mason and Dixon Survey Terminal Point |
| Matewan Historic District |
| McCausland, Gen. John, House |
| McDowell County Courthouse |
| New River Gorge Bridge |
| Nuttallburg Coal Mining Complex and Town Historic District |
| Old Bethany Church |
| Old Main, Bethany College |
| Old Main, Marshall University |
| Old Stone Church |
| Old Stone House |
| Old Stone House |
| Old Sweet Springs |
| Philippi Covered Bridge |
| Point Pleasant Battleground |
| Prato Rio |
| Quick, John Herbert, House |
| Reber Radio Telescope |
| Rehoboth Church |
| Rich Mountain Battlefield |
| Richwood Hall |
| Rumsey Hall |
| Scanlon Farm |
| Seneca Glass Company Building |
| Shepherdstown Historic District |
| Sistersville City Hall |
| Snodgrass Tavern |
| St. Albans Site |
| Starks, Samuel, House |
| Stealey-Goff-Vance House |
| Stephen, Adam, House |
| St. Peter's Roman Catholic Church |
| Tabb, Edward, House |
| Traveller's Rest |
| Tygart Valley Homesteads Historic District |
| Wade, Alexander, House |
| Washington, Charles, House |
| Wells Inn |
| Weston State Hospital |
| West Virginia Independence Hall |
| West Virginia State Penitentiary |
| Wheeling Baltimore and Ohio Railroad Passenger Station |
| Wheeling Suspension Bridge |
| Worthington, Robert, House |
Data from United States Park Service and Wikidata
