West Virginia - Significance region: Local
| Red Horse Tavern |
| Reed's Mill |
| Rees-Daniel Farm |
| Rees, John, David, and Jacob, House |
| Rees, Morris, III House |
| Reeves, John C., House |
| Rellim Farm |
| Renick Farm |
| Richwood Avenue Wall |
| Ridge Road Historic District |
| Rigas, Dr. George, House |
| Ripley Historic District |
| Ripon Lodge (Boundary Increase) |
| Ritchie County Courthouse |
| Riverside Iron Works Office Building |
| Riverside School |
| Robinson-Tabb House |
| Rockland |
| Rock Spring |
| Rocks, The |
| Rogers House |
| Ronceverte Historic District |
| Ropp, Baker, House |
| Ropp, R.C., House |
| Rose Hill Farm |
| Rosemont Historic District |
| Rotary Park Bridge |
| Ruble Church |
| Ruddell General Store |
| Rupert School |
| Rush-Miller House |
| Saint Charles Catholic Mission Church |
| Salem College Administration Building |
| Salem Historic District |
| Sam Black Church |
| Sarvis Fork Covered Bridge |
| Schlack, George, House |
| Scott Hill |
| Scrabble Historic District |
| Second Ward Negro Elementary School |
| Seebert Lane Colored School |
| Seibert, Henry J., II, House |
| Shannondale Springs |
| Sharon Lodge No. 28 IOOF |
| Shinn, Levi, House |
| Shinnston Historic District |
| Simms School Building |
| Simpson Creek Covered Bridge |
| Simpson Memorial Methodist Episcopal Church |
| Sites Homestead |
| Sixth Street Railroad Bridge |
| Sloat-Horn-Rossell House |
| Smith Building |
| Smith, Elven C., House |
| Smith-Giltinan House |
| Smithland Farm |
| Smith, Michael, House |
| Smith, Silas P., Opera, House |
| Smith, W.H., Hardware Company Building |
| Smoketown School |
| Smoot Theater |
| Snyder, Benjamin H., House |
| Snyder, Noah, Farm |
| Soldiers and Sailors Memorial Building |
| Sophia Historic District |
| South Charles Town Historic District |
| South Church Street Historic District |
| Southern Methodist Church Building |
| South Water Street Historic District |
| South Wheeling Historic District |
| Speck, Peter, House |
| Spencer Cemetery |
| Spencer Presbyterian Church |
| Springfield Brick House |
| Spring Grove |
| Spring Mills Historic District |
| Spring Valley Farm |
| St. Albans Chesapeake and Ohio Railroad Depot |
| St. Albans Main Street Historic District |
| St. Albans Post Office |
| St. Albans Railroad Industry Historic District |
| Stark, Henry and Julia Hoard, House |
| St. Bernard Church and Cemetery |
| St. Colman's Roman Catholic Church and Cemetery |
| Sterrett Brothers' Dry Goods Store |
| Stewart, David, Farm |
| Stewart's Tavern |
| St. George's Chapel |
| St. Mark's Episcopal Church |
| Stone House Mansion |
| Stoneleigh |
| Stone Manse |
| Stone Tavern at Roney's Point |
| St. Paul Baptist Church |
| Strayer-Couchman House |
| Strode-Morrison-Tabler House and Farm |
| Stuart Manor |
| Stuart, W. Scott, House |
| Stuckey House |
| Stump Family Farm |
Data from United States Park Service and Wikidata
