West Virginia - Significance region: Local
| Chapel of the Immaculate Conception of the Blessed Virgin Mary |
| Charleston Baptist Temple |
| Charleston Municipal Auditorium |
| Charles Town Mining, Manufacturing, and Improvement Company Building |
| Charles Town, Old, Historic District |
| Charmco Building |
| Charter, Lathrop Russell, House |
| Chesapeake and Ohio 1308 Steam Locomotive |
| Chesapeake and Ohio 2755 Steam Locomotive |
| Chesapeake and Ohio Depot |
| Chilton House |
| Chilton, W. E. II, House |
| Chrystal Water and Power Company-Spencer Water and Ice Company |
| Circleville School |
| Citizens National Bank |
| Citizens National Bank |
| Clary's Mountain Historic District |
| Clelland House |
| Clendenin Historic District |
| Clerc-Carson House |
| Coal House |
| Cockayne, Bennett, House |
| Colston, Edward, House |
| Contentment |
| Cook House |
| Cook's Mill |
| Cool Spring Farm |
| Cool Spring Farm |
| Cooper, Henry, House |
| Cooper's Mill |
| Cottrill Opera House |
| Couch-Artrip House |
| Cox, Judge Frank, House |
| Cox-Morton House |
| Cox-Parks House |
| Crawford-Gardner House |
| Crim, J. N. B., House |
| Cunningham-Hevener House |
| Cunningham House and Outbuildings |
| Cunningham, Samuel, House |
| Dalgain |
| Danner-Fletcher House |
| Darkesville Historic District |
| Davis Coal and Coke Company Administrative Building |
| Davis & Elkins College Historic District |
| Davis, Henry Glassaway, House |
| Dawson, T. H. B., House |
| Day-Vandevander Mill |
| Deckers Creek Wall |
| Dering Building |
| District Parsonage, Old |
| Downs, Charles, II, House |
| Downtown Buckhannon Historic District |
| Downtown Charleston Historic District |
| Downtown Charles Town Historic District |
| Downtown Elkins Historic District |
| Downtown Parkersburg Historic District |
| Downtown Richwood Historic District |
| Downtown Rowlesburg Historic District |
| Drinker, John, House |
| Dry Pond School |
| Duffields Depot |
| Dunbar Recreation Center |
| Dunbar School |
| Dunlow Norfolk & Western Railway Depot |
| Durham, E. A., House |
| Dutch Hollow Wine Cellars |
| Eastham House |
| East Martinsburg Historic District |
| East Wheeling Historic District |
| Ebenezer Chapel |
| Edgefield |
| Edgewood Historic District |
| Edgewood Manor |
| Eighth Street Stone Retaining Walls |
| Elk City Historic District |
| Elkins Milling Company |
| Elk River Coal and Lumber Company #10 Steam Locomotive |
| Elks Club |
| Elm Grove |
| Elmwood-on-the-Opequon |
| Estill, Wallace, Sr., House |
| Evans, John, House |
| Faber Double-Crib Barn |
| Fairmont Senior High School |
| Fairview |
| Fayetteville Esso Station |
| Fayetteville Historic District |
| Feagans' Mill Complex |
| Feay Inn |
| Federal Aviation Administration Records Center |
| Ferrell-Holt House |
| Fidler's Mill |
| First Baptist Church |
| First Baptist Church of Bluefield |
| First Congregational Church of Ceredo |
| First National Bank-Graham Building |
| First Presbyterian Church/Calvary Temple Evangelical Church |
| First Ward School |
| Fischer-Lasch Farmhouse |
Data from United States Park Service and Wikidata
