Tennessee - Significance region: Local
| “See Rock City” Barn |
| Senter-Rooks House |
| Sequatchie County Courthouse |
| Settlement School Community Outreach Historic District |
| Settlement School Dormitories and Dwellings Historic District |
| Seven Islands Methodist Church |
| Sevier County Courthouse |
| Sevier Station |
| Sevierville Commercial Historic District |
| Seward, John, House |
| Shackle Island Historic District |
| Shaddon Mill Site |
| Shadowlawn Historic District |
| Sharp, Elisha, House |
| Shaw, Abner T., House |
| Shea, John F., House |
| Shelbridge |
| Shelby Street Bridge |
| Shelbyville Courthouse Square Historic District |
| Shelbyville Railroad Station |
| Shelving Rock Encampment |
| Shields' Station |
| Shiflett, G. W., Barn |
| Shiloh Baptist Church |
| Shofners' Lutheran Church and Cemetery |
| Shook, Col. A. M., House |
| Shook-Vanzant Farm |
| Shrine Building |
| Shults Grove Methodist Church |
| Shute, Thomas, House |
| Signal Knitting Mills |
| Signal Mountain Elementary School |
| Signal Mountain Historic District |
| Simerly-Butler House |
| Simmons, Peter, House |
| Sims, Capt. William, House |
| Sims, John Green, House |
| Sitka School |
| Sixteen Tunnel |
| Skipwith Hall |
| Skullbone Store |
| Smith, Alexander, House |
| Smith-Carter House |
| Smith, Christopher H., House |
| Smith County Courthouse |
| Smith, Dr. Benjamin Franklin, House |
| Smith Farmhouse |
| Smith-Hoffman House |
| Smith-Little-Mars House |
| Smith, Robert Andrew, Farm |
| Smith, Robert H., Law Office |
| Smithson-McCall Farm |
| Smithson, Nathaniel, House |
| Smith, Warner Price Mumford, House |
| Smotherman House |
| Sneed, Constantine, House |
| Soldiers and Sailors Memorial Auditorium |
| Somerville Historic District |
| South Bluffs Warehouse Historic District |
| South College Street Historic District |
| South Elk Street Historic District |
| Southern Bell Telephone and Telegraph Building |
| Southern Engine and Boiler Works |
| Southern Methodist Publishing House |
| Southern Railroad Bridge |
| Southern Railroad Freight Depot |
| Southern Railway Freight Depot |
| Southern Railway Industrial Historic District |
| Southern Terminal and Warehouse Historic District |
| South Main Street Historic District |
| South Main Street Historic District |
| South Main Street Historic District |
| South Market Historic District |
| South Parkway-Heiskell Farm Historic District |
| South Pittsburg Historic District |
| South Pulaski Historic District |
| Southwestern at Memphis Historic District |
| Southwestern at Memphis Sorority Row Historic District |
| Sparkman-Skelley Farm |
| Sparta Electric Building |
| Sparta Nashville, Chattanooga and St. Louis Railroad Depot |
| Sparta Residential Historic District |
| Sparta Rock House |
| Speedway Terrace Historic District |
| Spence, John C., House |
| Sperry-Smith House |
| Spring Creek Presbyterian Church |
| Springfield Town Square Historic District |
| Spring Hill Presbyterian Church |
| Spring Place |
| Spring Street Service Station |
| Sprouse, Granville Babb, House |
| Squirewood Hall |
| Stacker, Samuel, House |
| Stagecoach Inn |
| Stagecoach Road |
| Standard-Coosa-Thatcher Mills |
| Standard Furnace (40HI145) |
| St. Ann's Episcopal Church |
| Stanton Masonic Lodge and School |
Data from United States Park Service and Wikidata
