South Dakota - Area of significance: Industry
| Bowden, Faye, House-Agnus Saunders |
| Deadwood Historic District |
| Excelsior Flour Mill |
| Fairmont Creamery Company Building |
| Farley-Loetscher Company Building |
| Farley-Loetscher Company Building I |
| Hansen, Peter, House |
| Harney Peak Tin Mining Company Buildings |
| Hayward, Orlan A., House |
| Hollands Grist Mill |
| Homestake Mining Company Hydroelectric Plant No. 2 |
| Jones, Mack, House |
| Keystone Trading Company Store |
| Lead Historic District |
| Maxon, Margaret and Vernon, House |
| Mitchell Lustron Historic District |
| Murtha, Charles, House and Brick Yard |
| Mystic Townsite Historic District |
| Nelson, Maurice, House |
| Old Courthouse and Warehouse Historic District |
| Opitz, Edbert and Josie, House |
| Queen Bee Mill |
| Reynolds, Grant J., House |
| Sample-Lindblaum House |
| Sexauer, George P., House |
| Sioux Falls Light and Power Hydro Electric Plant |
| Sturgis Water Works Company Supply Works Site |
| Welch, Laura M, House |
| Wesch, Phillip, House |
| Western Portland Cement Plant |
| Yankton Historic Commercial District |
Data from United States Park Service and Wikidata
