South Carolina - Significance region: State
| Abbeville County Courthouse |
| Abbeville Historic District |
| Aiken, Gov. William, House |
| Albion |
| Allen University |
| Allison Plantation |
| Allison, Robert Barnwell, House |
| Alston House |
| Altamaha Town |
| Anderson Downtown Historic District |
| Anderson House |
| Annandale Plantation |
| Antioch Christian Church |
| Arsenal Hill |
| Ashley River Historic District |
| Atlantic Beach Historic District |
| Babcock Building, South Carolina State Hospital |
| Balwearie |
| Bamberg, Gen. Francis Marion, House |
| Bamberg Historic District |
| Barber House |
| Barnwell-Gough House |
| Barratt House |
| Bates, William, House |
| Battery Gadsden |
| Battery Thomson |
| Belmont Neck Site-38KE06 |
| Belton Standpipe |
| Benedict College Historic District |
| Benson, Florence C., Elementary School |
| Biggin Church Ruins |
| Blocker House |
| Boundary Street-Newberry Cotton Mills Historic District |
| Boykin Mill Complex |
| Brattonsville Historic District |
| Brevard, Keziah Goodwyn Hopkins, House |
| Brice, Dr. Walter, House and Office |
| Broad Margin |
| Browntown |
| Buchan, A. H., Company Building |
| Buck's Upper Mill Farm |
| Buffalo Mill Historic District |
| Building at 1210-1214 Main Street |
| Building at 1644 Main Street |
| Building at 1722-1724 Main Street |
| Building at 303 Saluda Avenue |
| Burton House |
| Butler Family Cemetery |
| Byrd, J. A., Mercantile Store |
| Caldwell-Hampton-Boylston House |
| Caldwell Street Historic District |
| Calhoun County Courthouse |
| Callawassie Sugar Works |
| Cal Smoak Site |
| Campbell's Covered Bridge |
| Camp Welfare |
| Canal Dime Savings Bank |
| Cape Romain Lighthouses |
| Carroll, Chancellor James P., House |
| Castle Pinckney |
| Catholic Presbyterian Church |
| Cattle Creek Campground |
| Cauthen, Dr. William Columbus, House |
| Cedar Grove |
| Cedar Springs Historic District |
| Chapel of Hope |
| Charleston Naval Hospital Historic District |
| Cheraw Historic District |
| Cherokee Path, Sterling Land Grant |
| Chesnut Cottage |
| Chester Historic District |
| Church of the Cross |
| Church of the Holy Trinity |
| Civilian Conservation Corps Quarry No. 1 and Truck Trail |
| Civilian Conservation Corps Quarry No. 2 |
| Claflin College Historic District |
| Clemson College Sheep Barn |
| Clemson University Historic District I |
| Clemson University Historic District II |
| Clinton AME Zion Church |
| Clio Historic District |
| Coateswood |
| Coker, James L., III, House |
| College Street Historic District |
| Colleton County Courthouse |
| Columbia Commercial Historic District |
| Columbia Mills Building |
| Concord Presbyterian Church |
| Consolidated Building |
| Converse College Historic District |
| Cool Springs |
| Corinth Baptist Church |
| Cousins House |
| Craig House |
| Cross Keys House |
| Curtiss-Wright Hangar |
| Cypress Methodist Camp Ground |
| Darby Plantation |
| Dew Barn |
| Dillon County Courthouse |
Data from United States Park Service and Wikidata
