South Carolina - Role: Building
| Smyrna Baptist Church |
| Sottile, Giovanni, House |
| South Carolina Archives Building |
| South Carolina Governor's Mansion |
| South Carolina National Bank of Charleston |
| South Carolina State Armory |
| South Carolina State Arsenal |
| South Carolina State Hospital, Mills Building |
| South Carolina Statehouse |
| South Carolina State Library |
| South Carolina Western Railway Station |
| Southern Bleachery and Print Works |
| Southern Cotton Oil Company |
| Southern Railway Depot |
| Southern Railway Depot |
| Southern Railway Passenger Depot |
| Southern Railway Passenger Station |
| Spann, Dr. Cyril O., Medical Office |
| Spann Methodist Church and Cemetery |
| Sparrow, James, House |
| Spencer House |
| Spigner, A. Fletcher, House |
| Springfield High School |
| Springfield Plantation House |
| Spring Park Inn |
| Springs, Leroy, House |
| Spring Street Methodist Church |
| Standard Oil Company Headquarters |
| St. Andrew's Episcopal Church |
| St. Andrews Episcopal Church |
| State Theatre |
| St. David's Episcopal Church and Cemetery |
| Stevens-Dorn Farmstead |
| Stewart, James, House |
| St. George Rosenwald School |
| Stiles-Hinson House |
| Still Hopes |
| St. James' Church, Goose Creek |
| St. James Episcopal Church, Santee |
| St. James the Greater Catholic Mission |
| St. John's Lutheran Church |
| St. John's Lutheran Church |
| St. Julien Plantation |
| St. Luke's Church |
| St. Mark's Church |
| St. Mary Help of Christians Church |
| St. Mary's Roman Catholic Church |
| St. Michael's Episcopal Church |
| St. Michael's Evangelical Lutheran Church |
| Stokes-Mayfield House |
| Stone Manufacturing Company |
| Stoney Creek Independent Presbyterian Chapel of Prince William Parish |
| Stony Point |
| St. Paul's Methodist Church |
| St. Peter's Roman Catholic Church |
| St. Philip's Episcopal Church |
| St. Philip's Episcopal Church, Bradford Springs |
| St. Phillip School |
| Stradley and Barr Dry Goods Store |
| Stribling, J.C., Barn |
| Stroman, William P., House |
| Structural Science Building |
| St. Stephen's Episcopal Church |
| St. Stephen's Episcopal Church |
| St. Thaddeus Episcopal Church |
| Stuart, Col. John, House |
| Sturgis, R.L. and Annie, House |
| Sturkey, M. L. B., House |
| Sullivan House |
| Summer Brothers Stores |
| Summer Chapel, Prince Frederick's Episcopal Church |
| Summer Chapel Rectory, Prince Frederick's Episcopal Church |
| Summerton High School |
| Summit Plantation House |
| Sumter County Courthouse |
| Sumter Town Hall-Opera House |
| Sun Fun Motel |
| Sunnyside |
| Sunnyside |
| Supreme Court of South Carolina Building |
| Sword Gate Houses |
| Sylvan Building |
| Sylvania |
| Tabby Manse |
| Tall Oaks |
| Tanglewood Plantation |
| Taveau Church |
| Tawana Motel |
| Taylor, Earle R., House and Peach Packing Shed |
| Taylor House |
| Temple Sinai |
| Tennent, Josiah Smith, House |
| The Oaks |
| The Oaks |
| Thorntree |
| Thornwell-Elliott House |
| Thornwell-Presbyterian College Historic District |
| Thurmond, Strom, Federal Building and U.S. Courthouse |
| Tillman Hall |
| Tillman School |
Data from United States Park Service and Wikidata
