South Carolina - Role: Building
| Clemson College Sheep Barn |
| Cleveland Law Range |
| Clinton AME Zion Church |
| Clinton Chapel AME Zion Church |
| Coateswood |
| Cockfield, P.D., House |
| Coffin Point Plantation |
| Coffin Point Plantation Caretaker's House |
| Cohasset |
| Coker, James L., III, House |
| Coker, J. L., Company Building |
| Coker, Robert R., House |
| Coker, S. Pressly, House |
| Colding-Walker House |
| College of Charleston |
| Colleton County Courthouse |
| Colonial-Hites Company |
| Columbia Central Fire Station |
| Columbia City Hall |
| Columbia Electric Street Railway, Light & Power Substation |
| Columbia Mills Building |
| Columbia Township Auditorium |
| Commercial Hotel |
| Concord Presbyterian Church |
| Confederate Printing Plant |
| Consolidated Building |
| Converse Mill |
| Conway Methodist Church, 1898 and 1910 Sanctuaries |
| Conway Post Office |
| Cool Springs |
| Cope Depot |
| Copeland House |
| Corinth Baptist Church |
| Corley, C. E., House |
| Cornell Arms |
| Corner Packing Shed, The |
| Corner Store and Office, The |
| Cornwell, Harriet M., Tourist House |
| Cornwell Inn |
| Court Tennis Building |
| Cousins House |
| Cowpens Depot |
| Craig House |
| Crawford's Plantation House |
| Cross Keys House |
| Crossways |
| Culp House |
| Cureton House |
| Cureton-Huff House |
| Curtiss-Wright Hangar |
| Cuthbert, John A., House |
| Cypress Methodist Camp Ground |
| Dantzler, Col. Olin M., House |
| Dantzler Plantation |
| Darby Plantation |
| Dargan, Julius A., House |
| Darlington, Lyde Irby, House |
| Darlington Theatre |
| Davenport Apartments |
| Davenport House |
| Davidson Hall, Coker College |
| Davis House |
| Davis Plantation |
| Davis, Winnie, Hall |
| Dawkins, Judge Thomas, House |
| Dawson-Vanderhorst House |
| Deas, Edmund H., House |
| Debruhl-Marshall House |
| Denmark High School |
| Dennis High School |
| Denver Downs Farmstead |
| Derham, John P., House |
| Dew Barn |
| Dial, Allen, House |
| Dillard Barn |
| Dillon County Courthouse |
| Dillon Graded School and Dillon Public School |
| Dillon, James W., House |
| Dixie Library Building |
| Dock Street Theatre |
| Donalds Grange No. 497 |
| Donaldson, T. Q., House |
| Dorn, Joseph Jennings, House |
| Dorn's Flour and Grist Mill |
| Dove Dale |
| Dovillers-Manning-Magoffin House |
| Downtown Baptist Church |
| Drayton Hall |
| Drayton Mill |
| Dreher, Jacob Wingard, House |
| Duckett, Charles H., House |
| Dukes Gymnasium |
| Duncan, Bishop William Wallace, House |
| Duncan's Creek Presbyterian Church |
| Dunklin, James, House |
| Dunlap, C. K., House |
| Earle Town House |
| Easley High School Auditorium |
| East Main Street Historic District |
| Eau Claire Town Hall and Survey Publishing Company Building |
Data from United States Park Service and Wikidata