South Carolina - Criteria: C (architecture/engineering)
| Rose Hill Plantation House |
| Roselawn |
| Rosemary Hall |
| Rose, Thomas, House |
| Roseville Plantation |
| Ruff's Chapel |
| Rural Hall Plantation House |
| Rural Point |
| Russell-Heath House |
| Russell House |
| Russell, Nathaniel, House |
| Saint Thomas' Protestant Episcopal Church |
| Salem Black River Presbyterian Church |
| Salley Historic District |
| Salmon, George, House |
| Salters Plantation House |
| Saluda Theatre |
| Sams Plantation Complex Tabby Ruins |
| Santee Canal |
| Sapp, William Harrison, House |
| Scarborough, Henry Lee, House |
| Schuyler Apartments |
| Scott, Claudius, Cottage |
| Scott House |
| Seaboard Air Line Railway Depot |
| Seaboard Air Line Railway Depot in McBee |
| Seaboard Air Line Railway Depot in Patrick |
| Seabrook, John, Plantation Bridge |
| Seabrook, William, House |
| Seacoast Packing Company |
| Seaside Plantation |
| Seaside Plantation House |
| Seay, Jammie, House |
| Secessionville Historic District |
| Self, James C., House |
| Selkirk Farm |
| Seneca Historic District |
| Settlemyer House |
| Sharon Downtown Historic District |
| Sheldon Church Ruins |
| Sheriff Mill Complex |
| Shiloh Methodist Church |
| Shirley, Obediah, House |
| Sidney Park Colored Methodist Episcopal Church |
| Simmons-Edwards House |
| Simmons-Harth House |
| Simmons, Robert, House |
| Simpsonville Baptist Church |
| Simpson, William Dunlap, House |
| Sinclair Service Station |
| Singleton's Graveyard |
| Sitgreaves House |
| Slave Houses, Gregg Plantation |
| Slave Street, Smokehouse, and Allee, Boone Hall Plantation |
| Smalls, Robert, School |
| Smith Barn |
| Smith-Cannon House |
| Smith, J. Warren, House |
| Smith's Tavern |
| Smyrna Baptist Church |
| Snee Farm-Charles Pinckney National Historic Site |
| Socastee Historic District |
| South Carolina Governor's Mansion |
| South Carolina Memorial Garden |
| South Carolina National Bank of Charleston |
| South Carolina State Armory |
| South Carolina State Arsenal |
| South Carolina State College Historic District |
| South Carolina State Hospital, Mills Building |
| South Carolina Statehouse |
| South Carolina Western Railway Station |
| Southern Railway Depot |
| Southern Railway Passenger Depot |
| South Harper Historic District |
| South Main Historic District |
| South Street-South Church Street Historic District |
| Spann Methodist Church and Cemetery |
| Sparrow, James, House |
| Spartanburg Historic District |
| Spencer House |
| Spigner, A. Fletcher, House |
| Springfield High School |
| Springfield Plantation House |
| Springs, Leroy, House |
| Springwood Cemetery |
| SS WILLIAM LAWRENCE Shipwreck Site |
| Standard Oil Company Headquarters |
| St. Andrews Episcopal Church |
| Stateburg Historic District |
| St. David's Episcopal Church and Cemetery |
| Stevens-Dorn Farmstead |
| Stewart, James, House |
| St. Helena Parish Chapel of Ease Ruins |
| Stiles-Hinson House |
| Still Hopes |
| St. James' Church, Goose Creek |
| St. James Episcopal Church, Santee |
| St. James the Greater Catholic Mission |
| St. John's Historic District |
| St. John's Lutheran Church |
Data from United States Park Service and Wikidata
