South Carolina - Criteria: B (person)
| Smith, J. Warren, House |
| Snee Farm-Charles Pinckney National Historic Site |
| Snow's Island |
| South Main Historic District |
| Spencer House |
| Spratt Cemetery |
| Springs, Leroy, House |
| Stateburg Historic District |
| St. David's Episcopal Church and Cemetery |
| Stiles-Hinson House |
| St. Julien Plantation |
| Stony Point |
| Sturkey, M. L. B., House |
| Sunnyside |
| Tabby Manse |
| Tall Oaks |
| Taylor House |
| Tennent, Josiah Smith, House |
| Thornwell-Presbyterian College Historic District |
| Townsend's, Hephzibah Jenkins, Tabby Oven Ruins |
| Union Community Hospital |
| Valencia |
| Vance-Maxwell House |
| Vander Horst, Arnoldus, House |
| Vesey, Denmark, House |
| Voorhees College Historic District |
| Waxhaw Presbyterian Church Cemetery |
| Whaley, W. B. Smith, House |
| White, Elizabeth, House |
| Whitehall |
| Whitehall |
| White Plains |
| White, William Elliott, House |
| Willcox's |
| Williams, A.P., Funeral Home |
| Williams-Ball-Copeland House |
| Wilson, Thomas Woodrow, Boyhood Home |
| Witherspoon-Hunter House |
| Woodburn |
| Woodlands |
| Woodlands |
| Woodrow Memorial Presbyterian Church |
| Young Farm |
| Young, Virginia Durant, House |
| Zante Plantation |
Data from United States Park Service and Wikidata
