South Carolina - Area of significance: Transportation
| Aiken, William, House and Associated Railroad Structures |
| Ashley River Historic District |
| Ashley River Road |
| Atlantic Coast Line Railroad Depot |
| Bache, Alexander, U.S. Coast Survey Line |
| Belton Depot |
| Boykin Mill Complex |
| BROWN'S FERRY VESSEL |
| Cainhoy Historic District |
| Campbell's Covered Bridge |
| Cape Romain Lighthouses |
| Charleston Consolidated Railway, Electric and Gas Company Car House |
| Cheraw Historic District |
| Cherokee Path, Sterling Land Grant |
| Clio Historic District |
| Columbia Canal |
| Columbia Electric Street Railway, Light & Power Substation |
| Cooper River Historic District |
| Cope Depot |
| Cornwell, Harriet M., Tourist House |
| Cowpens Depot |
| Culclasure-Geiger Farmstead |
| Curtiss-Wright Hangar |
| Darlington Industrial Historic District |
| Dillon, James W., House |
| Foster's Tavern |
| Friendfield Plantation |
| Gaston Livery Stable |
| Georgetown Lighthouse |
| Gervais Street Bridge |
| Great Falls Depot |
| Greer Depot |
| Hartsville Passenger Station |
| Hobcaw Barony |
| Joye Cottage |
| Landsford Canal |
| Laurens Historic District |
| Lewis Inn |
| Mayesville Historic District |
| McCormick Train Station |
| McMakin's Tavern |
| Mount Pleasant Historic District |
| Nation Ford Road |
| Ninety Six National Historic Site |
| Old Georgetown Road |
| Pinewood Depot |
| Poinsett Bridge |
| Rear Lighthouse of Hilton Head Range Light Station |
| Rockville Historic District |
| Rosemary Hall |
| Russell House |
| Saluda Factory Historic District |
| Santee Canal |
| Seaboard Air Line Railway Depot |
| Seaboard Air Line Railway Depot in McBee |
| Seaboard Air Line Railway Depot in Patrick |
| Seabrook, John, Plantation Bridge |
| Seabrook, William, House |
| Sinclair Service Station |
| Smith's Tavern |
| South Carolina National Bank of Charleston |
| South Carolina Railroad |
| South Carolina Western Railway Station |
| Southern Railway Depot |
| Southern Railway Passenger Depot |
| Southern Railway Passenger Station |
| SS WILLIAM LAWRENCE Shipwreck Site |
| Stony Point |
| Strawberry Chapel and Childsbury Town Site |
| Stumphouse Tunnel Complex |
| Summerville Historic District |
| Union Downtown Historic District |
| Union Station |
| U.S. Highway 25 |
| Valencia |
| Waccamaw River Warehouse Historic District |
| Wescott Road |
| West Gervais Street Historic District |
| York Historic District |
Data from United States Park Service and Wikidata
