South Carolina - Area of significance: Historic - Non-aboriginal
| Aiken, Gov. William, House |
| Battery White |
| Belmont Neck Site-38KE06 |
| Big Lake Cattle Mound |
| Brady's Cattle Mound |
| BROWN'S FERRY VESSEL |
| Castle Pinckney |
| Cattle Mound #6 |
| Charlesfort-Santa Elena Site |
| Christ Church (Episcopal) and Churchyard |
| Columbia Canal |
| Columbia Commercial Historic District |
| Cook's Lake Cattle Mound |
| Cooner's Cattle Mound |
| Cooper River Historic District |
| Coopersville Ironworks Site (38CK2) and Susan Furnace Site (38CK67) |
| Cowpens Furnace Site (38CK73) |
| Dead River Cattle Mound |
| Dead River Dike |
| Dorn Gold Mine |
| Ellen Furnace Site (38CK68) |
| Fish Haul Archaeological Site (38BU805) |
| Folly North Site-38CH1213 |
| Fort Johnson/Powder Magazine |
| Fort Lyttelton Site |
| Fort Motte Battle Site |
| Fort Pemberton Site |
| Grimball, Paul, House Ruins |
| Historic Camden Revolutionary War Restoration |
| Honey Hill-Boyd's Neck Battlefield |
| House Plantation, Old |
| Jackson's Furnace Site (38YK217) |
| Keller Site |
| King Cemetery |
| King's Creek Furnace Site (38CK71) |
| Lands End Road Tabby Ruins |
| Landsford Canal |
| Lindley's Fort Site |
| Long Point Plantation (38CH321) |
| Manning Archeological Site |
| Medway |
| Minim Island Shell Midden (38GE46) |
| Mount Dearborn Military Reservation |
| Nesbitt's Limestone Quarry (38CK69) |
| Newington Plantation |
| Ninety Six National Historic Site |
| Old Dorchester |
| Pelham Mills Site (38GR165) |
| Pinckneyville |
| Pottersville |
| Pritchard, Paul, Shipyard |
| Richmond Hill Plantation Archeological Sites |
| Richmond Plantation |
| Rosemont Plantation |
| SAM Site |
| Sams Plantation Complex Tabby Ruins |
| Secessionville Historic District |
| Silver Bluff |
| Site of Old Charles Towne |
| Snee Farm-Charles Pinckney National Historic Site |
| Snow's Island |
| South Carolina Railroad |
| St. Helenaville Archaeological Site (38BU931) |
| St. Luke's Parish Zion Chapel of Ease Cemetery |
| Stockade, The |
| Stoney-Baynard Plantation |
| Thicketty Mountain Ore Pits (38CK74) |
| Townsend's, Hephzibah Jenkins, Tabby Oven Ruins |
| Trapp and Chandler Pottery Site (38GN169) |
| Welsh Neck-Long Bluff-Society Hill Historic District |
| White Hall Plantation House Ruins and Oak Avenue |
| Willtown Bluff |
Data from United States Park Service and Wikidata
