South Carolina - Area of significance: Exploration/Settlement
| Ashley River Road |
| Baker, William, House |
| Beaufort Historic District |
| Calhoun, Patrick, Family Cemetery |
| Cherokee Path, Sterling Land Grant |
| Dove Dale |
| Fig Island Site |
| Grimball, Paul, House Ruins |
| Groce, Augustus Belton and Margaret Wheeler, House |
| Hart, Thomas E., House, and Kalmia Gardens |
| Hoffman, George P., House |
| Lawton Park and Pavilion |
| Lindley's Fort Site |
| Long Cane Massacre Site |
| Ninety Six National Historic Site |
| Old White Meeting House Ruins and Cemetery |
| Oolenoy Baptist Church Cemetery |
| Powder Magazine |
| Salmon, George, House |
| Silver Bluff |
| Spratt Cemetery |
| St. James Episcopal Church, Santee |
| St. John's Lutheran Church |
| Waxhaw Presbyterian Church Cemetery |
| Zubly Cemetery |
Data from United States Park Service and Wikidata
