Pennsylvania - Significance region: National
| Seventh Street Bridge |
| Shawnee-Minisink Site |
| Sixth Street Bridge |
| Skippack Bridge |
| Smithfield Street Bridge |
| Society Hill Historic District |
| Soldiers and Sailors Monument |
| South Tenth Street Bridge |
| Southwark District |
| SS UNITED STATES (Steamship) |
| Staple Bend Tunnel |
| Starrucca Viaduct |
| St. Clement's Protestant Episcopal Church |
| St. David's Church and Graveyard |
| Steel Hopper Car No. 33164 |
| Steel Passenger Coach No. 1650 |
| Steel Passenger Coach No. 1651 |
| Stehli Silk Mill |
| Stenton |
| St. George's Methodist Church |
| Stiegel-Coleman House |
| Stirling, Maj. Gen. Lord, Quarters |
| St. John's Church |
| St. Mark's Episcopal Church |
| St. Marys Historic District |
| St. Nicholas Croatian Church |
| St. Peter's Church |
| St. Peter's Church |
| Strickler Site |
| Sturgis, Julius, Pretzel House |
| Sully, Thomas, Residence |
| Summerseat |
| Sutter, Johann Agust, House |
| Switcher No. 1670 |
| Switcher No. 94 |
| Tanner, Henry O., House |
| Taylor, George, House |
| Thaddeus Kosciuszko National Memorial |
| Thirtieth Street Station |
| Thomas, M. Carey, Library, Bryn Mawr College |
| Thomas Mill Covered Bridge |
| Thunderbird Lodge |
| Tindley Temple United Methodist Church |
| Trenton City/Calhoun Street Bridge |
| Trevose Manor |
| Tunkhannock Viaduct |
| Union Canal Tunnel |
| Union League of Philadelphia |
| Union School |
| University of Pennsylvania Campus Historic District |
| Upsala |
| U.S. Mint Building at Philadelphia |
| U.S. Naval Home |
| U.S. Post Office |
| USS BECUNA (SS-319) |
| U.S.S. NIAGARA |
| U.S.S. OLYMPIA |
| Valley Forge National Historical Park |
| Von Steuben, Gen. Frederick, Headquarters |
| Wagner Free Institute of Science |
| Waldenmark |
| Walnut Street Bridge |
| Walnut Street Bridge |
| Walnut Street Theatre |
| Wanamaker, John, Store |
| Washington Crossing State Park |
| Washington Memorial Chapel |
| Washington's Headquarters |
| Waterville Bridge |
| Waynesborough |
| WCAU Studios |
| Weaver, Henry, Farmstead |
| Weiser, Conrad, House |
| Weona Park Carousel |
| West, Benjamin, Birthplace |
| Westinghouse, George, Memorial Bridge |
| WFIL Studio |
| Whipple Dam State Park Day Use District |
| White Hall of Bristol College |
| Widow Maloby's Tavern |
| Wills Hospital |
| Wilson, August, House |
| Wissahickon Inn |
| Wooden Baggage Express No. 6 |
| Wooden Express Baggage No. 6076 |
| Wooden Hopper Gondola No. 1818 |
| Woodford |
| Woodlands, The |
| Woodmont |
| Worlds End State Park Family Cabin District |
| Wyck House |
| Wyeth, N.C., House and Studio |
| Wyoming Monument |
| Yeakle's Mill Bridge |
| Zimmermann, Marie, Farm |
Data from United States Park Service and Wikidata
