Pennsylvania - Significance region: National
| Cope, Edward Drinker, House |
| Coplay Cement Company Kilns |
| Coraopolis Bridge |
| Cornplanter Grant |
| Cornwall Iron Furnace |
| Coventry Hall |
| Coventryville Historic District |
| Cowans Gap State Park Family Cabin District |
| Cressbrook Farm |
| Cumberland Valley Car |
| Davis Island Lock and Dam Site |
| DDI Electric Locomotive No. 36 |
| Delaware Aqueduct |
| Delaware Division of the Pennsylvania Canal |
| Denison House |
| Deshler-Morris House |
| Dillingersville Union School and Church |
| Dilworthtown Historic District |
| Dobbin House |
| Downtown Johnstown Historic District |
| Drake Oil Well |
| Drexel and Company Building |
| Drinker's Court |
| Druim Moir Historic District |
| Dunlap's Creek Bridge |
| Eakins, Thomas, House |
| East Broad Top Railroad |
| Eastern State Penitentiary |
| Economy Historic District |
| Eisenhower National Historic Site |
| Elfreth's Alley Historic District |
| Ellicott, Andrew, House |
| Elliott, S. B., State Park Day Use District |
| Elliott, S. B., State Park Family Cabin District |
| Emmanuel Episcopal Church |
| Ephrata Cloister |
| Erie Land Lighthouse |
| Erie Railroad Station |
| Esherick, Margaret, House |
| Esherick, Wharton, Studio |
| Espy House |
| Evansburg Historic District |
| Experimental and Safety Research Coal Mines |
| Experimental Mine, U.S. Bureau Of Mines |
| Eyre, Wilson, House |
| Fair Hill Burial Ground |
| Fairmount Park |
| Fairmount Water Works |
| Fallingwater |
| Farmar Mill |
| Fighter’s Heaven |
| First Bank of the United States |
| First Presbyterian Church of West Chester |
| First Unitarian Church (Additional Data) |
| Fisher, Dr. Norman & Doris, House |
| Flat Car No. 473567 |
| Fonthill |
| Fonthill, Mercer Museum and Moravian Pottery and Tile Works |
| Fordhook Farm |
| Forester's Hall |
| Forks of the Ohio |
| Forrest, Edwin, House |
| Fort Mifflin |
| Fort Mifflin Hospital |
| Fort Necessity National Battlefield |
| Founder's Hall, Girard College |
| Frankford Arsenal |
| Franklin County Courthouse |
| Franklin Institute |
| Franklin Institute Science Museum |
| Frazier's, Joe, Gym |
| Free Quaker Meetinghouse |
| Freight Locomotive No. 5741 |
| French Creek State Park: Organized Group Camp 4 District |
| French Creek State Park Six Penny Day Use District |
| Friends Hospital |
| Fulton Opera House |
| Fulton, Robert, Birthplace |
| Furness Library |
| Gallatin, Albert, House; Friendship Hill National Historic Site |
| Gates, Gen. Horatio, House, and Golden Plough Tavern |
| Gemeinhaus-Lewis David De Schweinitz Residence |
| General Stores and Mold Loft Building-Harriman Yard of the Merchant Shipbuilding Corporation |
| George, Henry, Birthplace |
| Germantown Cricket Club |
| Gettysburg Battlefield Historic District |
| Gettysburg National Military Park |
| Gilpin Homestead |
| Girard College Complex |
| Glen Foerd at Torresdale |
| Gloria Dei (Old Swedes') Church National Historic Site |
| Graeme Park |
| Grandview Cemetery |
| Grange, The |
| Green Hills Farm |
| Greenwood Lake Dam |
| Grey Towers |
| Grey, Zane, House |
| Gruber Wagon Works |
| Grumblethorpe |
Data from United States Park Service and Wikidata
