Pennsylvania - Significance region: Local
| Ewart Building |
| Exton Hotel |
| Factory Bridge |
| Fagley House |
| Fairelawn |
| Fairfax Apartments |
| Fairfield Historic District |
| Fairmount Avenue Historic District |
| Fairmount Historic District |
| Fairville Historic District |
| Farmers and Mechanics Trust Company Building |
| Farmers Market |
| Farmer's Southern Market |
| Farragut, David, School |
| Fayette School |
| Fayette-Springs Hotel |
| Federal Barn |
| Federal Row |
| Federal Street School |
| Fell, D. Newlin, School |
| Feltons Mill Covered Bridge |
| Feltonville School No. 2 |
| Fenner-Snyder Mill |
| Ferguson, Joseph C., School |
| Ferguson, William, Farm |
| Ferron, John, House |
| Fetter's Mill |
| Fetter's Mill Village Historic District |
| Fifth Avenue High School |
| Finch Building |
| Findlay Farm |
| Finletter, Thomas K., School |
| Fireman's Drinking Fountain |
| First Baptist Church of Germantown |
| First Cambria AME Zion Church |
| First Church of Christ, Scientist |
| First Federal Savings and Loan Association of Philadelphia, Northeast Branch |
| First Methodist Episcopal Church of McKeesport |
| First National Bank in Fleetwood |
| First National Bank of Charleroi |
| Firstside Historic District |
| First United Presbyterian Church of Braddock |
| First Universalish Church of Sharpsville |
| Fischtner Covered Bridge |
| Fisher, Adam, Homestead |
| Fisher, Henry, House |
| Fisher, Maj. Jared B., House |
| Fisher's Lane |
| Fissel's School |
| Fitler School |
| Fitzsimons, Thomas, Junior High School |
| Fleischer, Helen, Vocational School |
| Fleisher, Samuel S., Art Memorial |
| Fleming, Molly, House |
| Florence Apartments |
| Follmer, Clogg and Company Umbrella Factory |
| Foos, Charles S., Elementary School |
| Ford, James, House |
| Ford Motor Company Assembly Plant |
| Forest Grove Historic District |
| Forge Hill |
| Forksville Covered Bridge |
| Forrest, Edwin, School |
| Forry House |
| Fort Ligonier Site |
| Fort McIntosh Site |
| Fort Pitt Elementary School |
| Fort Pittston School |
| Forty Fort Meetinghouse |
| Foster School |
| Fountain Hill Historic District |
| Fourth Avenue Historic District |
| Fowlersville Covered Bridge |
| Foxburg Country Club and Golf Course |
| Fox Chase Inn |
| Frank, Henry S., Memorial Synagogue |
| Franklin, Benjamin, School |
| Franklin Carpet Mill |
| Franklin County Jail |
| Franklin Historic District |
| Franklin Hose Company No. 28 |
| Franklinville School |
| Frantz School |
| Frehn Bridge |
| French Creek Farm |
| Frew, John, House |
| Frey, Jacob L., Tobacco Warehouse |
| Frick, Henry Clay, Training School for Teachers |
| Frick Park |
| Fricks Locks Historic District |
| Friedman, Henry B., Tobacco Warehouse |
| Friend, Philip, House |
| Frost, Josiah, House |
| Fullam, John and Alice, House |
| Fullerton Inn |
| Fulton Building |
| Fulton Elementary School |
| Fulton House |
| Fulton Log House |
| Fulton, Robert, School |
Data from United States Park Service and Wikidata