Pennsylvania - Significance region: Local
| Russell House |
| Ruter Hall |
| Ryerss Mansion |
| Ryon, Judge John, House |
| Ryot Covered Bridge |
| Sacred Heart General Hospital |
| Saeger, Edward, House |
| Salem Crossroads Historic District |
| Salem Evangelical Lutheran Church |
| Salem United Church of Christ |
| Sally Ann Furnace Complex |
| Saltsburg Historic District |
| Salvation Army Building, The |
| Sanatoga Union Sunday School |
| Sandoz Chemical Works |
| Sandy Hill Tavern |
| Sansom Row |
| Saturday Club |
| Sauer Buildings Historic District |
| Sawhill Covered Bridge |
| Scenery Hill Historic District |
| Schaeffer, Charles, School |
| Schaefferstown Historic District |
| Schall, William and Caroline, House |
| Schaumboch's Tavern |
| Schellsburg Historic District |
| Schenley High School |
| Schenley Park |
| Scherer, Frank C., Wagon Works |
| Schiller Elementary School |
| Schlegel, Christian, Farm |
| Schlicher, George F., Hotel |
| Schlichter Jute Cordage Company |
| Schnader, R. K. & Sons, Tobacco Warehouse |
| Schnader, Walter, Tobacco Warehouse |
| Schoettle, Edwin J., Company Building |
| Schoonover Mountain House |
| Schrot, Joseph F. and Anna B., Farm |
| Schultz, Martin, House |
| Schuylkill County Bridge No. 113 |
| Schuylkill County Bridge No. 114 |
| Scott Creek Bridge-North, Maryland and Pennsylvania Railroad |
| Scottdale Historic District |
| Scott, David, House |
| Scottish Rite Cathedral |
| Scott, James, House |
| Scott, Thomas, House |
| Scranton Chamber of Commerce Building |
| Scranton Electric Building |
| Scranton Lace Company |
| Search, George W., House |
| Second National Bank of Meyersdale |
| Seeds, Hugh D. and Martha S., Farm |
| Seel, William, Building |
| Segers, Redferd, House |
| Seipsville Hotel |
| Selinsgrove Hall and Seibert Hall |
| Sellers Hall |
| Sellers House |
| Seville Theatre |
| Sewickley Manor |
| Seyfert Mill |
| Seymour, Edward B., House |
| Shade Furnace Archeological District |
| Shade Gap Feed and Flour Mill |
| Shadyside Presbyterian Church |
| Shaffer's Bridge |
| Sharples Homestead |
| Sharples Separator Works |
| Sharpless Homestead |
| Sharpless, William C., House |
| Sharswood, George, School |
| Shaw, Anna Howard, Junior High School |
| Shaw Historic District |
| Sheads House |
| Sheard, Levi, Mill |
| Shedwick, John, Development Houses |
| Sheffield Apartments |
| Shelly School |
| Shelly, William, School and Annex |
| Shelter House |
| Sheridan, Philip H., School |
| Sherman, L. G., Tobacco Warehouse |
| Shields, David, House |
| Ship Inn |
| Shippen House |
| Shippen, Judge Henry, House |
| Shippensburg Historic District |
| Shoemaker, Capt. Jacob, House |
| Shoemaker Covered Bridge |
| Shoemaker, William, Junior High School |
| Shohola Glen Hotel |
| Short's Hotel |
| Shrawder-Sittig House |
| Shreiner Farm |
| Shrewsbury Historic District |
| Shrewsbury Railroad Station, Stewartstown Railroad |
| Siegfried's Dale Farm |
| Silkman House |
| Silver Lake Bank |
Data from United States Park Service and Wikidata
