Pennsylvania - Criteria: A (event)
| Schlegel, Christian, Farm |
| Schlicher Covered Bridge |
| Schlicher, George F., Hotel |
| Schnader, R. K. & Sons, Tobacco Warehouse |
| Schnader, Walter, Tobacco Warehouse |
| Schoonover Mountain House |
| Schrot, Joseph F. and Anna B., Farm |
| Schuylkill County Bridge No. 113 |
| Schuylkill County Bridge No. 114 |
| Scott Covered Bridge |
| Scott Creek Bridge-North, Maryland and Pennsylvania Railroad |
| Scottdale Armory |
| Scottdale Historic District |
| Scranton Armory |
| Scranton Chamber of Commerce Building |
| Scranton Lace Company |
| Searight's Fulling Mill |
| Searights Tollhouse, National Road |
| Second Bank of the United States |
| Second National Bank of Meyersdale |
| Seeds, Hugh D. and Martha S., Farm |
| Seel, William, Building |
| Seigrist's Mill Covered Bridge |
| Seipsville Hotel |
| Selinsgrove Hall and Seibert Hall |
| Seventh Street Bridge |
| Sewickley Manor |
| Seyfert Mill |
| Shade Furnace Archeological District |
| Shade Gap Feed and Flour Mill |
| Shadyside Presbyterian Church |
| Shaffer's Bridge |
| Sharples Separator Works |
| Sharpless, William C., House |
| Shaw, Anna Howard, Junior High School |
| Shaw Historic District |
| Sheads House |
| Sheard, Levi, Mill |
| Sheard's Mill Covered Bridge |
| Shearer's Covered Bridge |
| Shelly School |
| Shelly, William, School and Annex |
| Shelter House |
| Shenk's Mill Covered Bridge |
| Sherman, L. G., Tobacco Warehouse |
| Ship Inn |
| Shippen House |
| Shippensburg Historic District |
| Shoaf Historic District |
| Shoemaker Covered Bridge |
| Shohola Glen Hotel |
| Shreiner Farm |
| Shrewsbury Historic District |
| Shrewsbury Railroad Station, Stewartstown Railroad |
| Shriver Covered Bridge |
| Siegfried's Dale Farm |
| Silver Lake Bank |
| Simpson Street School |
| Sinking Springs Farms |
| Sixteenth Street Bridge |
| Sixth Street Bridge |
| Skinner Tavern |
| Slate Hill Cemetery |
| Slater Cigar Company |
| Slatington Historic District |
| Sleepy Hollow Hall |
| Slickville Historic District |
| Smaltz Building |
| Smock Historic District |
| Smyser and English Pharmacy |
| Snellenburg's Clothing Factory |
| Snooks Covered Bridge |
| Snyder, Caspar, House |
| Snyder Covered Bridge No. 17 |
| Snyder Mill |
| Social Service Building |
| Sodom Schoolhouse |
| Soldiers and Sailors Memorial Hall |
| Soldiers and Sailors Monument |
| Sonestown Covered Bridge |
| Southampton Baptist Church and Cemetery |
| South Bethlehem Downtown Historic District |
| South Fork Fishing and Hunting Club Historic District |
| South, George W., Memorial Protestant Episcopal Church of the Advocate |
| South Perkasie Covered Bridge |
| South Road Bridge, Northern Central Railway |
| South Side High School |
| South Tenth Street Bridge |
| South Ward School |
| South Wayne Historic District |
| Spalding Memorial Library-Tioga Point Museum |
| Spangler-Benner Farm |
| Spannuth Mill |
| Speakman No. 1 |
| Speakman No. 2, Mary Ann Pyle Bridge |
| Special Troops Armory |
| Spicker, Peter, House |
| Sprenger Brewery |
| Springdale Historic District |
| Springdale Historic District |
Data from United States Park Service and Wikidata
