Pennsylvania - Area of significance: Science
| Allegheny Observatory |
| Aluminum Research Laboratories |
| American Philosophical Society Hall |
| Bartram, John, House |
| Bryn Mawr |
| Carson, Rachel, House |
| Cope, Edward Drinker, House |
| Derbydown Homestead |
| Experimental and Safety Research Coal Mines |
| Fonthill |
| Fordhook Farm |
| Frankford Arsenal |
| Franklin Institute |
| Franklin Institute Science Museum |
| Gemeinhaus-Lewis David De Schweinitz Residence |
| Harlan House |
| Hill-Physick House |
| Lesley, J. Peter, House |
| Locust Grove |
| Longland |
| Marshall, Humphry, House |
| Marshall, Humphry, House |
| Massey, Thomas, House |
| Mercer Museum |
| Mill Grove |
| Mount Joy |
| Northumberland Historic District |
| Phipps Conservatory |
| Preston Laboratories |
| Priestley, Joseph, House |
| Pulpit Rocks |
| RittenhouseTown Historic District |
| Sellers Hall |
| Stenton |
| Tyler, John J., Arboretum |
| Wagner Free Institute of Science |
Data from United States Park Service and Wikidata
