Pennsylvania - Area of significance: Invention
| Acheson, Edward G., House |
| American Philosophical Society Hall |
| Combination Baggage and Mail Car No. 5403 |
| Consolidation Freight Locomotive No. 1187 |
| Consolidation Freight Locomotive No. 2846 |
| Consolidation Freight Locomotive No. 7688 |
| Coventry Hall |
| Cumberland Valley Car |
| DDI Electric Locomotive No. 36 |
| Dunlap's Creek Bridge |
| Flat Car No. 473567 |
| Frankford Arsenal |
| Franklin Institute |
| Franklin Institute Science Museum |
| Freight Locomotive No. 5741 |
| Fulton, Robert, Birthplace |
| Independence National Historical Park |
| Jacobsburg Historic District |
| Lancaster Watch Company |
| Landis Homestead |
| Lee Tire and Rubber Company |
| Lemoyne, Dr. Julius, House |
| McCormick, John B., House |
| Mikado Freight Locomotive No. 520 |
| Passenger and Baggage Car No. 4639 |
| Passenger Coach No. 3556 |
| Passenger Day Coach No. 8177 |
| Passenger Locomotive No. 1223 |
| Passenger Locomotive No. 1737 |
| Passenger Locomotive No. 460 |
| Passenger Locomotive No. 7002 |
| Sellers Hall |
| Sharples Separator Works |
| Steel Hopper Car No. 33164 |
| Steel Passenger Coach No. 1650 |
| Steel Passenger Coach No. 1651 |
| Stoner, Samuel, Homestead |
| Switcher No. 1670 |
| Switcher No. 94 |
| Wooden Baggage Express No. 6 |
| Wooden Express Baggage No. 6076 |
| Wooden Hopper Gondola No. 1818 |
Data from United States Park Service and Wikidata
