Pennsylvania - Area of significance: Industry
| Red Hill Historic District |
| Red Lion Borough Historic District |
| Reppert-Gabler House |
| Revloc Historic District |
| Reyburn Manufacturing Company Building |
| Rice's Landing Historic District |
| Rich-McCormick Woolen Factory |
| Ridgway Historic District |
| Ridley Creek State Park |
| Rieser Mill |
| RittenhouseTown Historic District |
| R. K. Laros Silk Mill |
| Roaring Spring Historic District |
| Roberts and Mander Stove Company Buildings |
| Robertsdale Historic District |
| Robesonia Furnace Historic District |
| Rockland Furnace |
| Ross Furnace |
| Rowland House |
| Royer, Daniel, House |
| Sally Ann Furnace Complex |
| Sandoz Chemical Works |
| Scherer, Frank C., Wagon Works |
| Schlichter Jute Cordage Company |
| Schnader, R. K. & Sons, Tobacco Warehouse |
| Schnader, Walter, Tobacco Warehouse |
| Schoettle, Edwin J., Company Building |
| Scottdale Historic District |
| Scott, James, House |
| Scranton Lace Company |
| Searight's Fulling Mill |
| Sellers Hall |
| Seyfert Mill |
| Shade Furnace Archeological District |
| Shade Gap Feed and Flour Mill |
| Sharples Separator Works |
| Shaw Historic District |
| Sheard, Levi, Mill |
| Sherman, L. G., Tobacco Warehouse |
| Shoaf Historic District |
| Simon, Herman, House |
| Simon, R. and H., Silk Mill |
| S.L. Allen & Company Building |
| Slater Cigar Company |
| Sleepy Hollow Hall |
| Slickville Historic District |
| Smaltz Building |
| Smock Historic District |
| Snellenburg's Clothing Factory |
| Snyder Mill |
| Spannuth Mill |
| Springdale Historic District |
| Springdale Mills |
| Springfield Mill |
| Spring Grove Borough Historic District |
| Spring Grove Farm and Distillery |
| Spring Grove Forge Mansion |
| Star Carpet Mill |
| Star Junction Historic District |
| Steel Heddle Manufacturing Company Complex |
| Stegmaier Brewery |
| Stehli Silk Mill |
| Stein Mill |
| Stiegel-Coleman House |
| Stover Mill |
| Stover-Myers Mill |
| St. Peters Village Historic District |
| Sturgis, Julius, Pretzel House |
| Sunbury Historic District |
| Sunrise Mill |
| Swatara Furnace |
| Sykes Brothers Yarn Mill |
| Tamaqua Historic District |
| Tannery, The |
| Tasty Baking Company Building |
| Taylor, Phillip, House |
| Teller Brothers-Reed Tobacco Historic District |
| Teller Cigar Factory |
| Terracina |
| The Elverson Building |
| Thomas Marble Quarry Houses |
| Thomas, William, House |
| Thompson Mill |
| Times Finishing Works |
| Tioga Mills |
| Titusville Historic District |
| Trenton City/Calhoun Street Bridge |
| Trimbleville Historic District |
| Tulpehocken Creek Historic District |
| Ulery Mill |
| Uneek Havana Cigar Company |
| Union City Historic District |
| United Cigar Manufacturing Company |
| Upper Roxborough Historic District |
| Vincent Forge Mansion |
| Wallace-Cross Mill |
| Walter, Henry, House |
| Wanner, Peter, Mansion |
| Warren Historic District |
| Warrenpoint |
Data from United States Park Service and Wikidata
