Pennsylvania - Area of significance: Commerce
| Dime Bank Building |
| Dime Savings and Trust Company |
| Doak-Little House |
| Doe Run Village Historic District |
| Dolington Village Historic District |
| Dollar Savings Bank |
| Dorneyville Crossroad Settlement |
| Dorrance Mansion |
| Dougherty, Philip, Tavern |
| Douglas, John S., House |
| Downer Tavern |
| Downtown Altoona Historic District |
| Downtown Indiana Historic District |
| Downtown Johnstown Historic District |
| Doylestown Historic District |
| Drake Hotel |
| Drexel and Company Building |
| Drovers Inn |
| Dubois Historic District |
| Dunbar-Creigh House |
| Durham Mill and Furnace |
| Eagle Tavern |
| Eakin, John, Farm |
| East Berlin Historic District |
| East Broad Top Railroad |
| East Center City Commercial Historic District |
| East Lancaster Avenue Historic District |
| East Liberty Commercial Historic District |
| East Liberty Market |
| Easton Historic District |
| Easton House |
| East Stroudsburg Railroad Station |
| Ebensburg Historic District |
| Economy Historic District |
| Ehrhart's Mill Historic District |
| Elder, Abraham, Stone House |
| Electric Locomotive No. 4859 |
| Elverson Historic District |
| Embreeville Historic District |
| Ephrata Commercial Historic District |
| Erie Railroad Station |
| Erie Trust Company Building |
| Estey Hall |
| Etna Furnace |
| Evansburg Historic District |
| Everett Historic District |
| Everhart, William, Buildings |
| Ewart Building |
| Fairfield Inn |
| Fairville Historic District |
| Farmar Mill |
| Farmers Market |
| Farmer's Southern Market |
| Fayette-Springs Hotel |
| Federal Row |
| Fidelity Mutual Life Insurance Company Building |
| Finch Building |
| First Federal Savings and Loan Association of Philadelphia, Northeast Branch |
| First National Bank in Fleetwood |
| Firstside Historic District |
| Flat Car No. 473567 |
| Fordhook Farm |
| Ford, James, House |
| Forest Grove Historic District |
| Fountain House |
| Fourth Avenue Historic District |
| Freight Locomotive No. 5741 |
| Frost, Josiah, House |
| Fullerton Inn |
| Fulton House |
| General Washington Inn |
| Girard Avenue West Historic District |
| Girard Commercial Historic District |
| Girard Group |
| Given, James, Tavern |
| Gladwyne Historic District |
| Glen Rock Historic District |
| Glen Rose Historic District |
| Globe Ticket Company Building |
| Good, John B., House |
| Gordon, Jervis, Grist Mill Historic District |
| Gosztonyi Savings and Trust |
| Graff's Market |
| Greencastle Historic District |
| Greensboro Historic District |
| Greensburg Downtown Historic District |
| Green Tree Tavern |
| Greenville Commercial Historic District |
| Gross Bridge |
| Haddington Historic District |
| Hager Building |
| Haines Mill |
| Hajoca Corporation Headquarters and Showroom |
| Half-Moon Inn |
| Hamburg Historic District |
| Hamorton Historic District |
| Hanover Historic District |
| Harmony Forge Mansion |
| Head House Square |
| Hendel Brothers, Sons and Company Hat Factory |
Data from United States Park Service and Wikidata
