Pennsylvania - Area of significance: Architecture
| Ruter Hall |
| Ryerss Mansion |
| Ryon, Judge John, House |
| Ryot Covered Bridge |
| Sacred Heart General Hospital |
| Saeger, Edward, House |
| Salem Evangelical Lutheran Church |
| Salem United Church of Christ |
| Sally Ann Furnace Complex |
| Saltsburg Historic District |
| Sanatoga Union Sunday School |
| Sandy Hill Tavern |
| Sansom Row |
| Sauer Buildings Historic District |
| Saxonburg Historic District |
| Scenery Hill Historic District |
| Schaeffer, Charles, School |
| Schaefferstown Historic District |
| Schall, William and Caroline, House |
| Schaumboch's Tavern |
| Schellsburg Historic District |
| Schenley Farms Historic District |
| Schenley High School |
| Schenley Park |
| Schiller Elementary School |
| Schlegel, Christian, Farm |
| Schlicher, George F., Hotel |
| Schnader, R. K. & Sons, Tobacco Warehouse |
| Schnader, Walter, Tobacco Warehouse |
| Schoonover Mountain House |
| Schrot, Joseph F. and Anna B., Farm |
| Schubert-Graber Log-Post Shop |
| Schultz, Martin, House |
| Scottdale Armory |
| Scottdale Historic District |
| Scott, David, House |
| Scottish Rite Cathedral |
| Scott, James, House |
| Scott, Thomas, House |
| Scranton Armory |
| Scranton Electric Building |
| Scranton Lace Company |
| Search, George W., House |
| Searight's Fulling Mill |
| Second Bank of the United States |
| Second National Bank of Meyersdale |
| Seeds, Hugh D. and Martha S., Farm |
| Seel, William, Building |
| Segers, Redferd, House |
| Seipsville Hotel |
| Sellers Hall |
| Sellers House |
| Seventeen-hundred-and-four House |
| Seville Theatre |
| Sewickley Manor |
| Seyfert Mill |
| Seymour, Edward B., House |
| Shadyside Presbyterian Church |
| Sharples Homestead |
| Sharpless Homestead |
| Sharpless, William C., House |
| Sharswood, George, School |
| Shaw, Anna Howard, Junior High School |
| Shaw Historic District |
| Sheads House |
| Sheard, Levi, Mill |
| Shedwick, John, Development Houses |
| Sheffield Apartments |
| Shelly School |
| Shelly, William, School and Annex |
| Shelter House |
| Sheridan, Philip H., School |
| Sherman, L. G., Tobacco Warehouse |
| Shields, David, House |
| Ship Inn |
| Shippen House |
| Shippen, Judge Henry, House |
| Shippensburg Historic District |
| Shoemaker, Capt. Jacob, House |
| Shoemaker, William, Junior High School |
| Shrawder-Sittig House |
| Shreiner Farm |
| Shrewsbury Historic District |
| Shrewsbury Railroad Station, Stewartstown Railroad |
| Siegfried's Dale Farm |
| Silkman House |
| Silver Lake Bank |
| Simon, Herman, House |
| Simpson Street School |
| Singer, John F., House |
| Sinking Springs Farms |
| Sinnott, Joseph, Mansion |
| Skinner Tavern |
| Skippack Bridge |
| Slater Cigar Company |
| Sleepy Hollow Hall |
| Slickville Historic District |
| Slifer House |
| Smalley, Lewis, Homestead |
| Smaltz Building |
Data from United States Park Service and Wikidata
