Ohio - Significance region: National
| SHOWBOAT MAJESTIC |
| Smith, Dr. Robert and Anne House |
| Spacecraft Propulsion Research Facility |
| Spring Grove Cemetery |
| Stan Hywet Hall-Frank A. Seiberling House |
| Steubenville Pottery Company Buildings |
| Succesful Sales |
| Taft Museum |
| Tawawa Chimney Corner |
| Temperance Row Historic District |
| Terrace Plaza Hotel |
| Tonkens, Gerald B. and Beverley, House |
| Tytus, John B., House |
| Union Terminal Group |
| Upton, Harriet Taylor, House |
| U.S. Post Office |
| USS COD (submarine) |
| Vesuvius Furnace |
| Village of Mariemont |
| Voice of America Bethany Relay Station |
| Warder, John Aston, House |
| Warther Family Home and Museum |
| Whitewater Shaker Settlement |
| William Howard Taft National Historic Site |
| W.P. SNYDER, JR. (steamboat) |
| Wright Brothers Hill-Memorial |
| Wright Cycle Company-Wright and Wright Printing Offices |
| Wright Flyer III |
| Young, Col. Charles, House |
| Youngstown Sheet and Tube Company Housing |
| Zero Gravity Research Facility (B-2) |
| Zoar Historic District |
| Zoar Historic District |
Data from United States Park Service and Wikidata
