Ohio - Significance region: Local
| Spring Grove Cemetery |
| Spring Grove Historic District |
| Spring Hill |
| Spruce Run Earthworks |
| Squire's Glen Farm |
| Squirrel-Forrest Historic District |
| Stackhouse Mound and Works |
| St. Adalbert Polish Catholic Church |
| Stadium Square Historic District |
| Stagecoach Inn |
| Stager-Beckwith House |
| Stahl-Hoagland House |
| Staley, Mr. and Mrs. Karl A., House |
| St. Aloysius-on-the-Ohio |
| St. Aloysius Orphanage |
| Stambaugh Building |
| Stambaugh, Henry H., Memorial Auditorium |
| Stanbery, Edwin, Office |
| Standard Building, The |
| Standart-Simmons Hardware Company |
| St. Andrew's Episcopal Church |
| Stanford, George, Farm |
| Stang, John, House |
| Stan Hywet Poultry Keepers Cottage |
| Stanley Block |
| St. Ann Roman Catholic Church Complex |
| Stanton Farm |
| Starr, Horace C., House and Carriage Barns |
| Starr-Truscott House |
| State Line Archeological District |
| Station Road Bridge |
| St. Augustine's Catholic Church |
| St. Boniface Roman Catholic Church, School, Rectory, and Convent of the Sister of the Precious Blood |
| St. Clair Hospital |
| St. Clair Street Historic District |
| St. Clairsville Historic District |
| Steamboat Hotel |
| Stearns, Edward R., House |
| Stearns, Lyman, Farm |
| Stearns, William, House |
| Stebbens Farm |
| Stedman-Shafer Grocery Warehouse Building |
| St. Edward Hotel |
| Steele's Hill-Grafton Hill Historic District |
| Steindam House |
| Steinkamp, Joseph G. House |
| Stengel, John S., House |
| Steubenville Commercial Historic District |
| Steubenville YMCA Building |
| Stewart-Hanson Farm |
| Stewart, Harry Bartlett, Property |
| Stewart Towers |
| St. Francis De Sales Church Historic District |
| St. Francis Seminary |
| St. Francis Xavier Church |
| St. Henry Roman Catholic Church and Rectory |
| St. Ignatius High School |
| Stites House |
| Stitt, David, Mound |
| Stivers High School |
| St. James Episcopal Church |
| St. James Episcopal Church |
| St. James Episcopal Church |
| St. John Catholic Church |
| St. John's AME Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Evangelical Lutheran Church |
| St. John's Evangelical Lutheran Church |
| St. John's Lutheran Church |
| St. John's Lutheran Church |
| St. John The Baptist Roman Catholic Church |
| St. Joseph Convent and Academy Complex |
| St. Joseph Roman Catholic Church |
| St. Joseph Roman Catholic Church Complex |
| St. Joseph's Church and Friary |
| St. Ladislaus Roman Catholic Church |
| St. Louis Church |
| St. Luke's Hospital |
| St. Mark’s Church and Rectory |
| St. Mark's Episcopal Church |
| St. Martin's Catholic Church |
| St. Mary Parish Hall |
| St. Mary Roman Catholic Church |
| St. Mary's Catholic Church |
| St. Mary's Catholic Church |
| St. Mary's Catholic School |
| St. Mary's Church and Rectory |
| St. Mary's Church of the Immaculate Conception |
| St. Mary's Girls Grade School |
| St. Mary's Hall, University Of Dayton |
| St. Mary's Of Morges |
| St. Mary's Rectory |
| St. Mary's Roman Catholic Church |
| St. Mary's Roman Catholic Church |
| St. Mary's School |
| St. Mary's School, Old |
| St. Michael the Archangel Catholic Church |
| Stockbridge Apartment Building |
Data from United States Park Service and Wikidata
