North Carolina - Significance region: Local
| Delta Farm |
| Demens-Rumbough-Crawley House |
| Dempsey-Reynolds-Taylor House |
| Denning, Thomas Marcellus, House |
| Depot Historic District |
| Depot Historic District |
| Desserette |
| Devane-MacQueen House |
| Dickinson Avenue Historic District |
| Dickson, Roger, Farm |
| Dilworth Historic District |
| Dixon-Leftwich-Murphy House |
| Dodd-Hinsdale House |
| Dorland Memorial Presbyterian Church |
| Double Shoals Cotton Mill |
| Dougherty Heights Historic District |
| Downtown Albemarle Historic District |
| Downtown Burlington Historic District |
| Downtown Elkin Historic District |
| Downtown Garner Historic District |
| Downtown Gastonia Historic District |
| Downtown Greensboro Historic District |
| Downtown Main Street Historic District |
| Downtown Mocksville Historic District |
| Downtown Mount Holly Historic District |
| Downtown North Historic District |
| Downtown Sanford Historic District |
| Downtown Selma Historic District |
| Downtown Smithfield Historic District |
| Downtown Sparta Historic District |
| Downtown Spruce Pine Historic District |
| Downtown Sylva Historic District |
| Downtown Taylorsville Historic District |
| Downtown Tryon Historic District |
| Downtown Wake Forest Historic District |
| Downtown Wilkesboro Historic District |
| Druid Hills Historic District |
| DuBois, W. E. B., School |
| Dudley, James Benson, Senior High School and Gymnasium |
| Duke Memorial United Methodist Church |
| Dula-Horton Cemetery |
| Dunavant Cotton Manufacturing Company |
| Dunn Commercial Historic District |
| Dupree-Moore Farm |
| Durham Cotton Mills Village Historic District |
| Durham Hosiery Mill No. 15 |
| Durham Hosiery Mills Dye House |
| Durham Hosiery Mills No. 2-Service Printing Company Building |
| Dyer, James B. and Diana M., HOuse |
| Eagle Nest |
| Earle W. Webb, Jr. Memorial Civic Center and Library |
| East Avenue Tabernacle Associated Reformed Presbyterian Church |
| East Broad Street-Davie Avenue Historic District |
| East Davis Street Historic District |
| East Durham Historic District |
| East End Historic District |
| East Main Street Historic District |
| East Main Street Historic District |
| East Marion-Belvedere Park Historic District |
| Eastover |
| East Raleigh Street Historic District |
| East Sanford Historic District |
| East Spencer Graded School |
| East Tennessee & Western North Carolina Railroad Locomotive No. 12 |
| East White Oak School, Former |
| Ebenezer Academy, Bethany Presbyterian Church and Cemetery |
| Ebenezer Methodist Church |
| Ebenezer Presbyterian Church |
| Eccles, Henry, House |
| Edenton Peanut Factory |
| Edenwood |
| Edgemont Historic District |
| Edgerton, Noah Edward, House |
| Edgewood |
| Edgewood |
| Edmondson-Woodward House |
| Edmunds-Heptinstall House |
| Edwards Hotel |
| Efird Building |
| Elizabeth City Cotton Mills |
| Elizabeth City Industrial Historic District |
| Elizabeth City Water Plant |
| Elizabeth Historic District |
| Elkin Creek Mill |
| Elkland School Gymnasium |
| Elk Park School |
| Ellerbe Springs Hotel |
| Eller, Joseph P., House |
| Ellerslie |
| Ellerson, William R. House |
| Ellington-Ellis Farm |
| Elliott-Carnegie Library |
| Ellis Street Graded School Historic District |
| Ellixson, William, House |
| Elm City Municipal Historic District |
| Elmore, Bruce A. and June L., Lustron House |
| Elmwood |
| Elmwood |
| Elmwood Plantation |
| Emanuel United Church of Christ |
Data from United States Park Service and Wikidata
