North Carolina - Criteria: C (architecture/engineering)
| South Broad-East Fifth Streets Historic District |
| South Broad Street Row |
| Southerland-Burnette House |
| Southern Pines Historic District |
| Southern Railway Company Overhead Bridge |
| Southern Railway Depot |
| Southern Railway Passenger Depot |
| Southern Railway Passenger Station |
| South Greensboro Historic District |
| South King Street Historic District |
| South Montreat Road Historic District |
| Southport Historic District |
| South Race Street Historic District |
| South River Presbyterian Church |
| South Trade Street Houses |
| South Union Street Courthouse and Commercial Historic District |
| South Union Street Historic District |
| Southwest Historic District |
| Sowers, Philip, House |
| Spach, Adam, Rock House Site |
| Spears House |
| Speas Vinegar Company |
| Speas, William Henry and Sarah Hauser, House |
| Speight-Bynum House |
| Speight House and Cotton Gin |
| Spencer Historic District |
| Sperling, George, House and Outbuildings |
| Spinning Wheel |
| Spoon, A. L., House |
| Spray Industrial Historic District |
| Spread Out Historic District |
| Spring Green Primitive Baptist Church |
| Spring Hill Methodist Protestant Church Cemetery |
| Spring Hope Historic District |
| Spruce Street YMCA |
| Sprunt, James D. and Frances, Cottage |
| Spurgeon House |
| SS. Peter and Paul's Russian Orthodox Greek Catholic Church |
| Stagg House |
| Stagville |
| St. Alban's Episcopal Church |
| Stallings-Carpenter House |
| St. Andrew's Episcopal Church and Cemetery |
| Stanly, Edward R., House |
| Stanly, John Wright, House |
| Star Historic District |
| Statesville Commercial Historic District |
| St. Athanasius Episcopal Church and Parish House and the Church of the Holy Comforter |
| Stauber, Samuel B., Farm |
| St. Barnabas Episcopal Church |
| Stedman, Frank H., House |
| Steele Creek Presbyterian Church and Cemetery |
| Sterling Cotton Mill |
| Sternberger, Sigmund, House |
| Stevens, Everitt P., House |
| Stevenson House |
| Stevens, Wayland H. and Mamie Burt, House |
| St. Frances Methodist Church |
| Stigerwalt, John, House |
| Stillwell, Erle, House II |
| St. James Episcopal Church and Rectory |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Missionary Baptist Church |
| St. Joseph African Methodist Episcopal Church |
| St. Joseph's Catholic Church |
| St. Joseph's Episcopal Church |
| St. Lawrence, Patrick, House |
| St. Luke's Church and Cemetery |
| St. Luke's Episcopal Church |
| St. Luke's Lutheran Church Cemetery |
| St. Mark's Episcopal Church |
| St. Mark's Episcopal Church |
| St. Mary's Chapel |
| St. Mary's Chapel |
| St. Mary's Church |
| St. Mary's College |
| St. Matthew's Episcopal Church and Churchyard |
| St. Matthew's Lutheran Church |
| St. Matthias Episcopal Church |
| Stockton |
| Stokes County Courthouse |
| Stokesdale Historic District |
| Stone Hedge |
| Stone, Joseph B., House |
| Stonewall |
| Stonewall Jackson Training School Historic District |
| Stovall, John W., Farm |
| St. Paul A.M.E. Church |
| St. Paul Baptist Church |
| St. Paul's Church and Cemetery |
| St. Paul's Episcopal Church and Cemetery |
| St. Paul's Episcopal Church and Churchyard |
| St. Paul's Methodist Episcopal Church South |
| St. Paul's Reformed Church |
| St. Paul's Roman Catholic Church |
| St. Philip's Church Ruins |
Data from United States Park Service and Wikidata
