North Carolina - Area of significance: Industry
| North Union Street Historic District |
| North Washington Avenue Workers' House |
| Oakdale Cotton Mill Village |
| O'Brien, William Thomas, House |
| Odell-Locke-Randolph Cotton Mill |
| Old Salem Historic District |
| Old Wilson Historic District |
| Orient Manufacturing Company-Chadwick-Hoskins No. 3 |
| Outen, R.F., Pottery |
| Oxford Historic District |
| Parks-Cramer Company Complex, Former |
| Pearl Mill Village Historic District |
| Penn House |
| Piedmont Buggy Factory |
| Piedmont Wagon Company |
| Pilot Hosiery Mill |
| Pilot Mill |
| Pineburr Hosiery Mill |
| Pine Street Creamery, (Former) |
| Pineville Mill Village Historic District |
| Powe House |
| Powell-Trollinger Lime Kilns |
| Proximity Print Works |
| Ragsdale Farm |
| Raleigh Electric Company Power House |
| Redmond-Shackelford House |
| Reed Gold Mine |
| Reidsville Historic District |
| Reinhardt-Craig House, Kiln and Pottery Shop |
| Renfro Mill |
| Revolution Cotton Mills |
| Reynolda Historic District |
| Reynolds Building |
| Reynolds, R.J., Tobacco Company Buildings 2-1 and 2-2 |
| Riverside Industrial Historic District |
| R. J. Reynolds Tobacco Company Buildings 82 and 83 |
| Roberdel Mill No. 1 Company Store |
| Robinson Rock House Ruin and Plantation Site |
| Rocky Mount Electric Power Plant |
| Rocky Mount Mills |
| Rocky Mount Mills Village Historic District |
| Roxboro Cotton Mill |
| Royal Baking Company |
| Royall Cotton Mill Commissary |
| Sanford Tobacco Company Redrying Plant and Warehouse |
| Santeetlah Hydroelectric Development |
| Saxapahaw Spinning Mill, Former |
| Seaboard Milling Company |
| Shamrock Mills |
| Sharpe, Col. Silas Alexander, House |
| Shelby Cotton Mill |
| Sherrill, John Carlyle and Anita, House |
| Shuping's Mill Complex |
| Single Brothers Industrial Complex Site |
| Smith Warehouse |
| Smith, W. F., and Sons Leaf House and Brown Brothers Company Building |
| Southern Asbestos Company Mills |
| Southern Railway Spencer Shops |
| South Main Street Historic District |
| South Trade Street Houses |
| South Union Street Historic District |
| Speight House and Cotton Gin |
| Spray Industrial Historic District |
| Stanley Mills |
| Statesville Commercial Historic District |
| Stepp's Mill |
| Sterling Cotton Mill |
| Sunny Side |
| Sunnyside-Central Terrace Historic District |
| Swansboro Historic District |
| Sykes, Joseph, Brothers Company Building |
| Taylor's Mill |
| Textile Mill Supply Company Building |
| Thomasville Downtown Historic District |
| Thrift Mill, Former |
| Tompkins, Daniel A., Company Machine Shop, Former |
| Trenton Cotton Mills |
| Troublesome Creek Ironworks |
| Turner, Henry, House and Caldwell-Turner Mill Site |
| Tyro Tavern |
| Union Tavern |
| Venable Tobacco Company Prizery and Receiving Room |
| Venable Tobacco Company Warehouse |
| Vesuvius Furnace |
| Wafco Mills |
| Waldensian Swiss Embroidery Company–Valdese Weavers, Inc. Mill |
| Walnut Hill Cotton Gin |
| Washington Historic District |
| Washington Mills-Mayodan Plant |
| Watts and Yuille Warehouses |
| Waughtown-Belview Historic District |
| West Badin Historic District |
| West Davis Street-Fountain Place Historic District |
| Western Electric Company-Tarheel Army Missile Plant |
| West Nash Street Historic District |
| West Point on the Eno |
| Whisnant Hosiery Mills |
| White Furniture Company |
| White Oak New Town Historic District |
| Wilkes Hosiery Mills |
Data from United States Park Service and Wikidata
