North Carolina - Area of significance: Engineering
| Apalachia Hydroelectric Project |
| Barber, J.T., School |
| Bodie Island Light Station |
| Bynum Bridge |
| Cape Fear Civil War Shipwreck Discontiguous District |
| Cape Hatteras Light Station |
| Carolina Transfer and Storage Company Building, (Former) |
| Chatuge Hydroelectric Project |
| Cheoah Hydroelectric Development |
| Church of St. Lawrence |
| Cotton Press |
| Cross Rock Rapid Sluice |
| CSS NEUSE (Ironclad Gunboat) |
| Deep River Camelback Truss Bridge |
| Dismal Swamp Canal |
| DIXIE ARROW (shipwreck and remains) |
| Eagle Falls Sluice |
| Edenton Station, United States Fish and Fisheries Commission |
| Elizabeth City Water Plant |
| Elmore, Bruce A. and June L., Lustron House |
| E.M. CLARK (shipwreck and remains) |
| EMPIRE GEM (shipwreck and remains) |
| First Presbyterian Church |
| Fontana Hydroelectric Project |
| Fort Caswell Historic District |
| Fort Macon |
| Gravel Shoals Sluice |
| Guastavino, Rafael, Sr., Estate |
| Hambley-Wallace House |
| Hangars 4 and 5, Pope Air Force Base |
| Hiwassee Hydroelectric Project |
| HMT BEDFORDSHIRE (shipwreck and remains) |
| Hunting Creek Railroad Bridge |
| Jacob's Creek Landing |
| J. S. Dorton Arena |
| King Street Overhead Bridge |
| Lake Mattamuskeet Pump Station |
| LANCING (shipwreck) |
| LIGHT VESSEL 71 (shipwreck) |
| Lockville Dam, Canal and Powerhouse |
| Loewenstein, Edward and Frances S., House |
| Madison-Derr Iron Furnace |
| Masonic Temple Building |
| Mayo River Sluice |
| McCulloch's Gold Mill |
| McKay, John A., House and Manufacturing Company |
| Melton-Fortune Farmstead |
| Mingus Mill |
| Mooresville Water Pump and Filter Plant |
| Moratock Iron Furnace |
| Narrows Dam and Power Plant Complex |
| Newland Road Site |
| Oak Island Lighthouse |
| Pembroke High School, Former |
| Pisgah Community Covered Bridge |
| Raleigh Banking and Trust Company Building |
| Raleigh Water Works and E.B. Bain Water Treatment Plant |
| Reynoldstown Historic District |
| Roanoke Canal |
| Roberson's Fish Trap Shoal Sluice |
| Santeetlah Hydroelectric Development |
| Scuppernong River Bridge |
| Skeen's Mill Covered Bridge |
| Slink Shoal Sluice and Wing Dams |
| Southern Railway Company Overhead Bridge |
| Sunset Avenue Public Works Historic District |
| Tanyard Shoal Sluice |
| Three Ledges Shoal Sluice |
| Union Storage and Warehouse Company Building |
| USS HURON |
| USS MONITOR |
| USS NORTH CAROLINA |
| U.S.S. PETERHOFF |
| Walnut Hill Cotton Gin |
| West Fork Pigeon River Pratt Truss Bridge |
| White Furniture Company |
| Wide Mouth Shoal Sluice |
Data from United States Park Service and Wikidata
