New York - Significance region: Local
| Searle, Gardner and Company Cuff and Collar Factory |
| Seawanhaka Corinthian Yacht Club |
| Second and Ostrander Historic District |
| Second Baptist Church of Dover |
| Second Baptist Church of Wayne |
| Second Baptist Society of Ulysses |
| Second Old School Baptist Church of Roxbury |
| Second Reformed Dutch Church of Kingston |
| Second Walton Armory (Thrity-third Separate Company) |
| Sedgwick House |
| Seeley Cottage |
| Seeley, Erskine L., House |
| Seeley Farmhouse |
| Seguine House |
| Seippel Bakery and Richard Apartments |
| Selfridge & Langford Building |
| Selkirk Lighthouse |
| Senator Street Historic District |
| Seneca Avenue East Historic District |
| SENECA CHIEF (shipwreck) |
| Seneca County Courthouse Complex at Ovid |
| Seneca Falls Village Historic District |
| Seneca-Onderdonk-Woodward Historic District |
| Seneca Park East and West |
| Seneca Plumbing and Heating Company Building |
| Seneca Presbyterian Church |
| Sennett Federated Church and Parsonage |
| Servoss House |
| Settle, John, Farm |
| Seven Oaks Estate |
| Seventh Day Baptist Church |
| Seville Hotel |
| Shaari Zedek Synagogue |
| Shady Brook Farm |
| Shady Glen Road Stone Arch Bridge |
| Shafer, Jacob, House |
| Shantz Button Factory |
| Sharon Springs Historic District |
| Sharp Brothers House |
| Sharp Burial Ground |
| Sharpe Homestead and Cemetery |
| Sharp Farmhouse |
| Shattuck House |
| Shay's Warehouse and Stable |
| Shay, William, Double House |
| Shear Homestead |
| Shear, Israel, House |
| SHEARWATER (schooner) |
| Shea's Seneca Building |
| Sheffield Farms Stable |
| Shelburne Playhouse |
| Sheldon Cobblestone House |
| Sheldon Farmhouse |
| Sheldon, Hazard H., House |
| Sheldon-Owens Farm |
| Shell House, The |
| Shelp, John, Cobblestone House |
| Shelter Island Country Club |
| Shepard Family Houses |
| Shepard Settlement Cemetery |
| Shepherd, William, House |
| Sherbrook Apartments |
| Sherburne High School |
| Sherburne Historic District |
| Sherman Free Library |
| Sherman House |
| Sherrill, Stephen, House |
| Sherwood Family Estate |
| Sherwood House |
| Sherwood-Jayne House |
| Shew, Godfrey, House |
| Shingleside |
| Shipley, Isaac, House |
| Shirts, William, House |
| Shoecraft, Matthew, House |
| Shore Cottage |
| Shore Farm |
| Shore Road Historic District |
| Short, Andrew, House |
| Shorter House |
| Shuart-Van Orden Stone House |
| Shute Octagon House |
| Sibley and Holmwood Candy Factory and Witkop and Holmes Headquarters |
| Sibley-Elmdorf Historic District |
| Sibley, Hiram, Homestead |
| Sibley's, Lindsay and Curr Building |
| Sibley Triangle Building |
| Sidewalk Clock at 1501 3rd Avenue, Manhattan |
| Sidewalk Clock at 161-11 Jamaica Avenue, New York, NY |
| Sidewalk Clock at 200 5th Avenue, Manhattan |
| Sidewalk Clock at 519 3rd Avenue, Manhattan |
| Sidewalk Clock at 522 5th Avenue, Manhattan |
| Sidewalk Clock at 783 5th Avenue, Manhattan |
| Sidney Historic District |
| Silk Street Bridge |
| Silliman Memorial Presbyterian Church |
| Sill Tenant House |
| Silver Bay Association Complex |
| Silver Lake Cemetery |
| Silver Lake Dam |
Data from United States Park Service and Wikidata
