New York - Area of significance: Commerce
| Schoharie Valley Railroad Complex |
| Second Street Historic District |
| Seippel Bakery and Richard Apartments |
| Seneca Plumbing and Heating Company Building |
| Seneca River Crossing Canals Historic District |
| Shea's Seneca Building |
| Sherman House |
| Sibley and Holmwood Candy Factory and Witkop and Holmes Headquarters |
| Sidewalk Clock at 1501 3rd Avenue, Manhattan |
| Sidewalk Clock at 161-11 Jamaica Avenue, New York, NY |
| Sidewalk Clock at 200 5th Avenue, Manhattan |
| Sidewalk Clock at 519 3rd Avenue, Manhattan |
| Sidewalk Clock at 522 5th Avenue, Manhattan |
| Sidewalk Clock at 783 5th Avenue, Manhattan |
| Simons General Store |
| Sinclair, Rooney & Co. Building |
| Sloat's Dam and Mill Pond |
| Smith's Grain and Feed Store |
| Sodus Point Lighthouse |
| Soho Historic District |
| Somers Hamlet Historic District |
| South Ann Street-Mill Street Historic District |
| South Buffalo North Side Light |
| South Salina Street Downtown Historic District |
| South Side Bank of Buffalo |
| South Street Seaport |
| South Street Seaport Historic District |
| South Village Historic District |
| Spring House |
| Stage Coach Inn |
| State Street Historic District |
| Stewart, A. T., Company Store |
| Stockade Historic District |
| Stone Arch Bridge |
| Stone Grist Mill Complex |
| Stone Street Historic District |
| Stony Brook Grist Mill |
| Stony Point Lighthouse |
| Stoops Hotel |
| Sweet, Samuel, Canal Store |
| Sylvester Manor |
| Syracuse Savings Bank |
| Talcott Falls Site |
| Tanner Block |
| Tarrytown Lighthouse |
| Terminal Building |
| The Great Atlantic and Pacific Tea Company Warehouse |
| Third National Bank |
| Thirty Mile Point Light |
| Three Squares Historic District |
| Tiffany and Company Building |
| Tioga Centre General Store |
| Tompkins Street Historic District |
| Town and Country Building |
| Tripp House and Store Complex |
| Tryon, Frank and Eliza, House |
| Turner Brothers' Building-American Household Storage Company |
| Unadilla Village Historic District |
| Union and State Streets Historic District |
| Union Savings Bank |
| U.S. Customhouse |
| U.S. Customhouse |
| U.S. Customshouse |
| U.S. Post Office |
| Utica Steam and Mohawk Valley Cotton Mill |
| Valcour Island Lighthouse |
| Van Buren, John, Tavern |
| Van Denbergh-Simmons House |
| Van Tassell and Kearney Horse Auction Mart |
| Village of Antwerp Historic District |
| Village of Greenwich Historic District |
| Villard Houses |
| Voelcker, Conrad, House |
| Vosburg Turning Mill Complex |
| V. Santini, Inc. Warehouse |
| Wallace Company Department Store |
| Wall and Hanover Building |
| Wall Street Historic District |
| Walnut Street Historic District |
| Walter's Hot Dog Stand |
| Walton and Willett Stone Store |
| Ward, M. J., Feed Mill Complex |
| Warsaw Downtown Historic District |
| Warwick Village Historic District |
| Waterford Village Historic District |
| Waterloo Downtown Historic District |
| Waterville Triangle Historic District |
| Watervliet Shaker Historic District |
| Watervliet Side Cut Locks |
| Watkins Glen Commercial Historic District |
| WAVERTREE |
| Wedgeway Building |
| West Broadway Commercial Historic District |
| West, George, House |
| Westport Historic District |
| West Stockholm Historic District |
| West Strand Historic District |
| West Street Building |
| Whedon-Schumacher House |
| Wheeler Hill Historic District |
Data from United States Park Service and Wikidata
