Missouri - Significance region: National
| Lock and Dam No. 25 Historic District |
| Loew's Midland Theater-Midland Building |
| Longview Farm |
| Lyric Theater |
| Majors, Alexander, House |
| Maramec Iron Works District |
| Mark Twain Historic District |
| Missouri Botanical Gardens |
| Moniteau County Courthouse Square |
| Montgomery Archeological Site |
| Mutual Musicians' Foundation Building |
| "New Santa Fe ""Three Trails"" Trail Swales" |
| Noland, Smallwood V., House |
| Nova Scotia Ironworks Historic District |
| O'Bryan Ridge Archeological District |
| Old Fort |
| Old Laclede Gas and Light Company Building |
| Old Stone Hill Historic District |
| Owens-McCoy House |
| Ozark Iron Furnace Stack |
| Pappas, Theodore, A., House |
| Patee, John, House |
| Pelster, Wilhelm, House-Barn |
| Pershing, Gen. John J., Boyhood Home |
| Phillips, Homer G., Hospital |
| Pony Express Stables |
| Ralls County Courthouse and Jail-Sheriff's House |
| Ravenswood |
| Research Cave |
| Rich Wood Archeological Site |
| Rockhill Neighborhood |
| Sanborn Field and Soil Erosion Plots |
| Santa Fe Trail-Grand Pass Trail Segments |
| Santa Fe Trail-Minor Park, Kansas City, Trail Segments |
| Santa Fe Trail-Saline County Trail Segments |
| Santa Fe Trail-Santa Fe Trail Park, Independence Trail Segments |
| Scarritt, William Chick, House |
| Schwarzer, Franz, House |
| Second Presbyterian Church |
| Shelley House |
| Simmons, Arthur, Stables Historic District |
| Sioux Passage Park Archeological Site |
| Springfield National Cemetery |
| Ste. Genevieve Historic District |
| St. Francis Xavier Parish Church & Rectory |
| St. John Nepomuk Parish Historic District |
| St. John's Episcopal Church |
| St. Johns-Laplant IV Archeological District |
| St. Louis Air Force Station |
| St. Louis Union Station |
| St. Paul's Episcopal Church |
| St. Stanislaus Seminary |
| St. Vincent's Hospital |
| Tavern Cave |
| Temple Site |
| Thomson, Gen. David, House |
| Tower Grove Park |
| Truman, Harry, Birthplace Memorial |
| Truman, Harry S, Historic District |
| TWA Corporate Headquarters' Building |
| Twain, Mark, Birthplace Cabin |
| Twain, Mark, Boyhood Home |
| Union Station |
| Union Trust Company Building |
| Unitarian Church of the Messiah |
| University City Plaza |
| U.S. Customhouse and Post Office |
| Utz Site |
| Wainwright Building |
| Wainwright Tomb |
| Ward, Seth E., Homestead |
| Washington University Hilltop Campus Historic District |
| Watkins Mill |
| Westminster College Gymnasium |
| Weston Historic District |
| White Haven; Ulysses S. Grant National Historic Site |
| Wholesale Row |
| Wilborn-Steinberg Site |
| Wilder, Laura Ingalls, House |
| Wilson's Creek National Battlefield |
| Winston Churchill Memorial |
| Young, Solomon, Farm-Truman, Harry S., Farm |
Data from United States Park Service and Wikidata
