Missouri - Role: Building
| Sacred Heart Church, School and Rectory |
| Safeway No. 357 |
| Safeway Stores and Office and Warehouse Building |
| Saint Louis Provident Association Building |
| Saint Matthew's Parish Complex |
| Saint Paul's Episcopal Church |
| Saline County Courthouse |
| Salisbury School |
| Sander, Augustus, House |
| Sanford B. Ladd School |
| Sanitol Building |
| Sanning, P.A., Store |
| Sappington, Joseph, House |
| Sappington, Thomas J., House |
| Sappington, William B., House |
| Sappington, Zephaniah, House |
| Saratoga Lanes Building |
| Saverton School |
| Savings Trust Company of St. Louis |
| Savoy Hotel and Grill |
| Scarritt Building and Arcade |
| Scarritt, Edward Lucky, House |
| Scarritt, Rev. Nathan, House |
| Scarritt, William Chick, House |
| Schlichtig House |
| Schmidt, Charles J. and Clara B. House |
| Schmidt House |
| Schmitt, Anton, House |
| Schneider, Henry, Building |
| Schnier, Fred, Building |
| Schollmeyer Building |
| Schoonover House |
| Schowengerdt, Ernst, House |
| Schroer, J. F., House-Store |
| Schwarzer, Franz, House |
| Schwegmann, John F., House |
| Scott, Charles Smith, Memorial Observatory |
| Scott County Courthouse |
| Scottish Rite Cathedral |
| Scruggs-Vandervoort-Barney Warehouse |
| Scudder Motor Truck Company Building |
| Sears, Roebuck and Company Warehouse Building |
| Second Baptist Church |
| Second Baptist Church |
| Second Christian Church |
| Second Presbyterian Church |
| Security Building |
| Sedalia Public Library |
| Seed, Miles A., Carriage House |
| Sehrt, August, House |
| Selkirk, Ben J. and Sons, Building |
| Senior Hall |
| Seven Gables Building |
| Seven Oaks School |
| Seventh District Police Station |
| Seven-Up Company Headquarters |
| Sewall Paint and Glass Company Building |
| Shamrock Court |
| Shankman Building |
| Shanley Building |
| Shaughnessy, Martin, Building |
| Shelby-Nicholson-Schindler House |
| Shelby, Thomas, House |
| Shell Building, The |
| Shelley House |
| Shelley, William Francis, House |
| Sherwood Manufacturing Company Building |
| Shivelbine, August and Amalia, House |
| Shoat, Hazel, House |
| Shobe-Morrison House |
| Shrine of Our Lady of Sorrows |
| Shriners' Hospital for Crippled Children |
| Sickles Tavern |
| Sigma Alpha Epsilon Building |
| Sikeston St. Louis, Iron Mountain and Southern Railway Depot |
| Silk Exchange Building |
| Simmons Colored School |
| Simonsen School |
| Simpson's College |
| Slatten House |
| Sligo Iron Store Co. Buildings |
| Smith Academy and Manual Training School |
| Smith, Dr. E. Sanborn, House |
| Smith House |
| Smith, James, House |
| Smith, Lawrence, House |
| Smith, William F., House |
| Smith, W.J. and Ed, Building |
| Sojourners Club |
| Sommerer, John M. and Lillian, House |
| Sophian Plaza |
| Southeast Grand Avenue and Fifth Street Residential Historic District |
| Southeast Missourian Building |
| South Middle Street Historic District |
| South Side National Bank |
| Southwestern Bell Administration Building |
| Southwestern Bell Repeater Station-Wright City |
| Sowers, Peter J., House |
| Spaunhorst and Mayn Building |
| Speigle House |
Data from United States Park Service and Wikidata
