Missouri - Criteria: C (architecture/engineering)
| Sigma Alpha Epsilon Building |
| Sikeston St. Louis, Iron Mountain and Southern Railway Depot |
| Simmons Colored School |
| Slatten House |
| Smith, Dr. E. Sanborn, House |
| Smith House |
| Smith, Orie J., Black and White Stock Farm Historic District |
| Smith, W.J. and Ed, Building |
| Sojourners Club |
| Sommerer, John M. and Lillian, House |
| Sophian Plaza |
| South Avenue Commercial Historic District |
| Southeast Missourian Building |
| South Fourth Street Commercial Historic District |
| South Liberty Courthouse Square Historic District |
| South Main Street Historic District |
| South Main Street Historic District |
| South-McDaniel-Patton Commercial Historic District |
| South Middle Street Historic District |
| South Side National Bank |
| South Sixth Street Historic District |
| Southwestern Bell Repeater Station-Wright City |
| Sowers, Peter J., House |
| Speigle House |
| S. Pfeiffer Manufacturing Company Headquarters |
| Spratt-Allen-Aull House |
| Springfield Warehouse and Industrial Historic District |
| Squibb, E.R. and Sons, Building |
| Squier Park Historic District |
| Stafford-Olive Historic District |
| St. Albans Farms Stone Barn |
| Standard Printing Company |
| Standard Theatre |
| Starke-Meinershagen-Boeke Rural Historic District |
| Stark, Gov. Lloyd Crow, House and Carriage House |
| Staudinger-Grumke House-Store |
| St. Augustine`s Roman Catholic Church |
| St. Charles Historic District |
| St. Charles Odd Fellows Hall |
| Steelcote Manufacturing Company Paint Factory |
| Ste. Genevieve Historic District |
| Steins, Jacob, House |
| Stenzel, R.O. & Company, Warehouse |
| Stephens College, South Campus |
| Stephens, Hugh and Bessie, House |
| Stevens, Edward A., House |
| St. Ferdinand's Shrine Historic District |
| St. Francis de Sales Church |
| St. Francis Xavier Catholic Church and Rectory |
| St. Francis Xavier School |
| St. Francois County Jail and Sheriff's Residence |
| Stickney, William A., Cigar Company Building |
| Stine and McClure Undertaking Company Building |
| St. Joe Lead Company Administration Building |
| St. John's Episcopal Church |
| St. John's Evangelical Lutheran Church and Parochial School |
| St. John's Mercy Hospital Building |
| St. Joseph Church |
| St. Joseph City Hall |
| St. Joseph Public Library |
| St. Joseph Public Library-Carnegie Branch |
| St. Joseph's Commerce and Banking Historic District |
| St. Joseph's Roman Catholic Church |
| St. Jude's Episcopal Church |
| St. Liborius Church and Buildings |
| St. Louis and San Francisco Railroad Building |
| St. Louis Colored Orphans Home |
| St. Louis, Iron Mountain and Southern Railroad Depot |
| St. Louis, Iron Mountain and Southern Railroad Depot |
| St. Louis Mart and Terminal Warehouse |
| St. Louis Post-Dispatch Printing Building |
| St. Louis-San Francisco Railroad Depot |
| St. Louis Theatre |
| St. Louis Union Station |
| St. Ludger Catholic Church |
| St. Mark the Evangelist Catholic Church, Convent and Academy |
| St. Mary of Victories Church |
| St. Mary's Church |
| St. Mary's Episcopal Church |
| St. Mary's Episcopal Church |
| St. Mary's of the Barrens Historic District |
| Stockstrom, Charles, House |
| Stockton Community Building |
| Stockton, Robert Henry, House |
| Stoddard County Courthouse |
| Stonebrook |
| Stone Chapel |
| Stone County Courthouse |
| Stone Houses |
| Stone Row |
| Stork Inn |
| St. Oswald's Protestant Episcopal Church |
| Stoutimore, David L. and Sallie Ann, House |
| St. Paul Catholic Church |
| St. Paul's Church |
| St. Paul's Episcopal Church |
| St. Peter's Catholic Church |
| St. Peter's Episcopal Church |
| St. Peter the Apostle Catholic Church and Rectory |
| St. Philip's Episcopal Church |
Data from United States Park Service and Wikidata
