Missouri - Area of significance: Social History
| Roaring River State Park Shelter Kitchen No. 2 and Rest Room |
| Robert Newsom Farmstead |
| Robnett-Payne House |
| Rock House, Edgewood Children's Center |
| Ross, John, House |
| Sacred Heart Church, School and Rectory |
| Saint Louis Provident Association Building |
| Saline County Courthouse |
| Sam A. Baker State Park Historic District |
| Santa Fe Place Historic District |
| Sappington, Thomas J., House |
| Savoy Hotel and Grill |
| Scarritt, Edward Lucky, House |
| Scarritt, Rev. Nathan, House |
| Scarritt, William Chick, House |
| Schowengerdt, Ernst, House |
| Scottish Rite Cathedral |
| Second Presbyterian Church |
| Shelley House |
| Sigma Alpha Epsilon Building |
| Sojourners Club |
| Soulard Neighborhood Historic District |
| Spofford Home for Children |
| Standard Theatre |
| St. James A.M.E. Church |
| St. Joe Lead Company Administration Building |
| St. Joseph Church |
| St. Joseph Public Library |
| St. Joseph Public Library-Carnegie Branch |
| St. Joseph's Roman Catholic Church |
| St. Mary's Church |
| St. Mary's Institute of O'Fallon |
| Stockton Community Building |
| Stone Houses |
| Stork Inn |
| St. Paul Catholic Church |
| Strassberger's Conservatory |
| Stumbaugh Post No. 180 GAR Hall |
| Stumberg, Dr. John H., House |
| St. Vincent's College Building |
| St. Vincent's Hospital |
| Sugar Lake State Park Open Shelter |
| Taille de Noyer |
| Thilenius, Col, George C., House |
| Tiger Hotel |
| Trinity Episcopal Church |
| Turner Hall |
| Unitarian Church of the Messiah |
| University City Plaza |
| Uptown Building and Theatre |
| Vallet-Danuser House |
| Van Meter State Park Combination Building |
| Van Meter State Park Shelter Building |
| Violette, Merritt, House |
| Volker, William, House |
| Wagoner Place Historic District |
| Wallace House |
| Walnut Inn |
| Ward, Seth E., Homestead |
| Warner, Maj. William, House |
| Washington School |
| Washington State Park CCC Historic District |
| Watson, Samuel Stewart, House |
| West Eleventh Street Historic District |
| West Ninth Street-Baltimore Avenue Historic District |
| Weston Historic District |
| White Haven; Ulysses S. Grant National Historic Site |
| Wholesale District |
| Willing, Dr. George M., House |
| Wilson's Creek National Battlefield |
| Wood Building |
| Woodneath |
| WPA Stock Barn and Pavilion |
| YWCA, Phyllis Weatley Branch |
Data from United States Park Service and Wikidata
