Missouri - Area of significance: Architecture
| Ryan Block |
| Sacred Heart Catholic Church and Parsonage |
| Sacred Heart Church, School and Rectory |
| Safeway No. 357 |
| Saint Matthew's Parish Complex |
| Saint Paul's Episcopal Church |
| Saline County Courthouse |
| Salisbury Square Historic District |
| Sam A. Baker State Park Historic District |
| Sancta Maria in Ripa |
| Sander, Augustus, House |
| Sanford Avenue Historic District |
| Sanford B. Ladd School |
| Sanitol Building |
| Sanning, P.A., Store |
| Santa Fe Place Historic District |
| Sappington, Joseph, House |
| Sappington, Thomas J., House |
| Sappington, William B., House |
| Sappington, Zephaniah, House |
| Savings Trust Company of St. Louis |
| Savoy Hotel and Grill |
| Scarritt Building and Arcade |
| Scarritt, Edward Lucky, House |
| Scarritt Point North Historic District |
| Scarritt Point South Historic District |
| Scarritt, Rev. Nathan, House |
| Scarritt, William Chick, House |
| Schlichtig House |
| Schmidt, Charles J. and Clara B. House |
| Schmidt House |
| Schmitt, Anton, House |
| Schnier, Fred, Building |
| Schollmeyer Building |
| Schoonover House |
| Schowengerdt, Ernst, House |
| Schroer, J. F., House-Store |
| Schwarzer, Franz, House |
| Schwegmann, John F., House |
| Scott, Charles Smith, Memorial Observatory |
| Scott County Courthouse |
| Scottish Rite Cathedral |
| Scruggs-Vandervoort-Barney Warehouse |
| Sears, Roebuck and Company Warehouse Building |
| Second Presbyterian Church |
| Security Building |
| Sedalia Commercial Historic District |
| Sedalia Public Library |
| Seed, Miles A., Carriage House |
| Sehrt, August, House |
| Senior Hall |
| Seven Gables Building |
| Seven Oaks School |
| Seventh District Police Station |
| Sewall Paint and Glass Company Building |
| Shamrock Court |
| Shankman Building |
| Shanley Building |
| Shaughnessy, Martin, Building |
| Shaw Avenue Place |
| Shelby-Nicholson-Schindler House |
| Shelby, Thomas, House |
| Shell Building, The |
| Shelley, William Francis, House |
| Shivelbine, August and Amalia, House |
| Shobe-Morrison House |
| Shrine of Our Lady of Sorrows |
| Sickles Tavern |
| Sigma Alpha Epsilon Building |
| Sikeston St. Louis, Iron Mountain and Southern Railway Depot |
| Silk Exchange Building |
| Simmons Colored School |
| Simonsen School |
| Simpson-Yeomans-Country Side Historic District |
| Slatten House |
| Smith, Dr. E. Sanborn, House |
| Smith House |
| Smith, Orie J., Black and White Stock Farm Historic District |
| Smith, W.J. and Ed, Building |
| Sojourners Club |
| Sophian Plaza |
| Soulard Neighborhood Historic District |
| Soulard-Page District |
| South Avenue Commercial Historic District |
| Southeast Grand Avenue and Fifth Street Residential Historic District |
| Southeast Green Street Historic Cottage District |
| Southeast Missourian Building |
| Southeast Third Street and Southeast Corder Avenue Ranch House Historic District |
| Southeast Third Street Residential Historic District |
| South Fourth Street Commercial District |
| South Fourth Street Commercial Historic District |
| South Hyde Park Historic District |
| South Liberty Courthouse Square Historic District |
| South Main Street Historic District |
| South Main Street Historic District |
| South-McDaniel-Patton Commercial Historic District |
| South Middle Street Historic District |
| South Side Historic District |
| South Side National Bank |
| South Sixth Street Historic District |
Data from United States Park Service and Wikidata
