Mississippi - Area of significance: Architecture
| Sand Spring Presbyterian Church |
| Saragossa |
| Saunders-Paine House, The |
| Scales, William Henry, House |
| Scenic Drive Historic District |
| Scherck, R. T., House |
| Scherer House |
| Scranton Historic District |
| Seashore Campground School |
| Second Street Historic District |
| Sedgewood Plantation |
| Selma Plantation House |
| Shadyside |
| Shaw Consolidated School |
| Shaw Homestead |
| Shaw-Nosser House |
| Shearwater Historic District |
| Shelton House |
| Sherman Line Rosenwald School |
| Shlenker House |
| Short's Hill |
| Shrock House |
| Shubuta Baptist Church |
| Shubuta Methodist Episcopal Church, South |
| Sillers, Walter, Sr., House |
| Simmons Farmhouse |
| Simmons House |
| Simmons House |
| Simpson County Courthouse |
| Sims-Brown House |
| Sims House |
| Smart-Griffin House |
| Smith, A. L., House |
| Smith-Buntura-Evans House |
| Smith, Charles F., House |
| Smithland |
| Smith-McClain-Buckley House |
| Smith Park Architectural District |
| Snowdoun |
| South Central Aberdeen Historic District |
| South Cherry Street Historic District |
| South Church Street Historic District |
| South College Street Historic District |
| South Columbus Historic District |
| South Division Street Historic District |
| South Drummond Street Neighborhood Historic District |
| Southeast Senatobia Historic District |
| South Lamar Historic District |
| South Main Historic District |
| South Panola Street Historic District |
| Southside Neighborhood Historic District |
| Southtown Historic District |
| South Vicksburg Public School No. 200 |
| South Ward Street Historic District |
| Southwest Gulfport Historic District |
| Southwest Holly Springs Historic District |
| Southwest Midtown Historic District |
| Southworth House |
| Spann, Pearl, Elementary School |
| Spengler's Corner Historic District |
| Spengler-Thomas Building |
| Spight, F. L., House |
| Spinks Plantation |
| Springfield Plantation |
| Spring Hill Missionary Baptist Church |
| Stafford's Wells Hotel |
| Stanton Hall |
| States Area Neighborhood Historic District |
| Steele, L. C., House |
| Stephenson-Allen House |
| Stevens-Buchanan House |
| Stevenson Primary School |
| St. Francis Xavier Convent |
| St. Mary's By the River |
| St. Matthew Evangelical Lutheran Church |
| Stogner House |
| Stone-Reid House |
| Storer House |
| St. Patrick Catholic Church |
| St. Paul's Episcopal Church Rectory, Old |
| St. Peter's Episcopal Church |
| Strawberry Patch-McKay House |
| Stringer House |
| Sub Rosa |
| Sullivan-Charnley Historic District |
| Summer Trees |
| Sunnyslope |
| Suter House |
| Swetman, Glenn, House |
| Sycamore Street Historic District |
| Sykes-Leigh House |
| Symons House |
| Tabernacle Methodist Church |
| Tabor, Dr. Joseph A., House |
| Tait-Taylor House |
| Tallahatchie County Second District Courthouse |
| Tanglewood |
| Tanglewood |
| Tate County Agricultural High School Historic District |
| Tate County Courthouse |
Data from United States Park Service and Wikidata
