Minnesota - Significance region: Local
| Sons of Italy Hall |
| Soo Line Depot |
| Soo Line Depot |
| South Broadway Historic District |
| Southern Minnesota Depot |
| South German Street Historic District |
| South Pike Bay Site |
| Spangenberg, Charles, Farmstead |
| Spangenberg, Frederick, House |
| Sparre Barn |
| Sperry, Albert H. and Jennie C., House |
| Spicer, John M., Summer House and Farm |
| Spina Hotel |
| Sprague, David R. and Ellsworth A., Houses |
| Spring Valley Carnegie Library |
| Spring Valley Mausoleum |
| Spring Valley Methodist Episcopal Church |
| St. Agatha's Conservatory of Music and Arts |
| St. Anthony Park Branch Library |
| Stanton, Lewis H., House |
| Station 13 Minneapolis Fire Department |
| Station 28 Minneapolis Fire Department |
| St. Benedict's Convent and College Historic District |
| St. Charles City Bakery |
| St. Cloud Commercial Historic District |
| St. Croix Boom Company House and Barn |
| St. Croix Lumber Mills-Stillwater Manufacturing Company |
| St. Croix River Access Site |
| Stearns County Courthouse and Jail |
| Steensland Library-St. Olaf College |
| Steffens, Ephraim, House |
| Sterling Congregational Church |
| Stevens, I.W., Lakeside Cottage |
| Stevens Square Historic District |
| Stewart, William E., House |
| St. George Serbian Orthodox Church |
| Stiklestad United Lutheran Church |
| Stillwater Commercial Historic District |
| St. James Hotel |
| St. John's Lutheran Church |
| St. Joseph's Academy |
| St. Joseph's Church-Catholic |
| St. Joseph's Hospital Nurses Home |
| St.Louis County District Courthouse |
| St. Mark's African Methodist Episcopal Church |
| St. Mark's Episcopal Chapel |
| St. Mary's Church of the Purification-Catholic |
| St. Mary's Hall |
| St. Mary's Hospital Dairy Farmstead |
| St. Matthew's School |
| St. Michael's School and Convent |
| St. Nicholas Orthodox Church |
| St. Olafs Norwegian Lutheran Church |
| Stordahl Building |
| Stout, James C. and Agnes M., House |
| St. Paul Casket Company |
| St. Pauli Norwegian Evangelical Lutheran Church |
| St. Paul Public/James J. Hill Reference Library |
| St. Peter Armory |
| St. Peter Carnegie Library |
| St. Peter Central School |
| St. Peter Commercial Historic District |
| Strangers Refuge Lodge Number 74, IOOF |
| Strong, William, House |
| Strong, William, House |
| Strunk-Nyssen House |
| Strutwear Knitting Company Building |
| Sts. Peter and Paul Russian Orthodox Church |
| St. Stefan's Romanian Orthodox Church |
| Stuntz Bay Boathouse Historic District |
| Stussi, Henry, House |
| Sugar Loaf |
| Sugar Loaf Brewery |
| Summer Branch Library |
| Sunset Beach Hotel |
| Superior Packing Company Plant |
| Supervisor's Office Headquarters |
| Svenska Mission Kyrka i Sodre Maple Ridge |
| Swede Prairie Progressive Farmers' Club |
| Swedish Evangelical Lutheran Church |
| Swedish Evangelical Lutheran Church |
| Swensson, Olof, Farmstead |
| Swift County Courthouse |
| Swinford Townhouses and Apartments |
| Tanner's Hospital |
| Taralseth, K.J., Company |
| Taylors Falls Public Library |
| Terrace Historic District |
| Terrace Mill Historic District |
| Thayer Hotel |
| Theopold Mercantile Co. Wholesale Grocery Building |
| The Woman’s Club of Minneapolis |
| Thief River Falls Auditorium and Municipal Building |
| Thief River Falls Public Library |
| Thirty-sixth Street Branch Library |
| Thoirs, Alexander, House |
| Thompson-Fasbender House |
| Thompson Flats |
| Thompson, Hannah C. and Peter E., House |
| Thompson Summer House |
Data from United States Park Service and Wikidata
