Michigan - Significance region: Local
| Sprague, Thomas S., House |
| Springwells Park Historic District |
| Stafford, Frederick H. and Elizabeth, House |
| Stafford House |
| Stafford, W. R., Flour Mill and Elevator |
| Stafford, W. R., Planing Mill Site |
| Stafford, W. R., Worker's House |
| Stancer-Road-North Coldwater River Bridge |
| Starkweather Religious Center |
| Starkweather School |
| State Hospital Gatehouse |
| St. Augustine Catholic Church and Cemetery |
| St. Bonaventure Monastery |
| St. Catherine of Siena Roman Catholic Parish Complex |
| St. Cecilia Society Building |
| St. Charles Borromeo Roman Catholic Parish Complex |
| St. Clair Flats South Channel Range Lights |
| St. Clair Inn |
| Stearns, Frederick, Building |
| Stearns, Frederick K., House |
| Stedman, Sarah Lowe, House |
| Stevens, Andrew J., House |
| Stickney Summer House-Bowers Harbor Inn |
| St. James Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Episcopal Church |
| St. John's Lutheran Church |
| St. John's Lutheran Church |
| St. John's-St. Luke's Evangelical Church |
| St. John the Baptist Catholic Church |
| St. John the Baptist Catholic Church Complex |
| St. Josaphat's Roman Catholic Church Complex |
| St. Joseph County Courthouse |
| St. Joseph North Pier Inner and Outer Lights |
| St. Joseph's Episcopal Church |
| St. Joseph's Episcopal Church |
| St. Joseph's Roman Catholic Church |
| St. Mary Cathedral |
| St. Mary of Good Counsel Catholic Church |
| St. Mary's Academy Historic District |
| St. Mary's Assumption Catholic Church |
| St. Mary's Church Complex Historic District |
| Stolberg, Charles, House |
| Stone School |
| Stony Creek Bridge |
| Stout House |
| Stow-Hasbrouck House |
| Strand Theatre and Arcade |
| Strasburg, Herman, House |
| Striker, Daniel, House |
| Sts. Peter and Paul Academy |
| St. Stanislaus Bishop and Martyr Roman Catholic Parish Complex |
| St. Theresa of Avila Roman Catholic Parish Complex |
| Stuart Area Historic District |
| Stuber-Stone Building |
| Sturgeon, Robert H., House |
| Sturm, Louis, House |
| St. Vincent DePaul Catholic Church, Convent, and School |
| Sugar Hill Historic District |
| Superior Street Commercial Historic District |
| Sutherland, Landgford and Lydia McMichael, Farmstead |
| Sutton, Nathan Esek and Sarah Emergene, House |
| Swanson, John, House |
| Swayze Apartments |
| Swayze, E. S., Drugstore/Otisville Mason Lodge No. 401 |
| Taliaferro, Thomas W. and Margaret, House |
| Taylor, Elisha, House |
| Tecumseh Downtown Historic District |
| Tecumseh Historic District |
| Temple Beth-El |
| Temple Beth-El |
| Temple, Samuel W., House |
| Ten Curves Road-Manistique River Bridge |
| Thayer, H. Elmer, House |
| The Clay School |
| Third Precinct Police Station |
| Third Reformed Church |
| Third Reformed Church of Holland |
| Thompson, Gamaliel, House |
| Thompson Home |
| Thompson Road-Air Line Railroad Bridge |
| Thornapple River Drive Bridge |
| Thunder Lake II Site |
| Tibbits Opera House |
| Tinker, Harry C., House |
| Tinlinn Apartments |
| Todd, Edwin, House |
| Tomlinson, Samuel J., House |
| Torrey, Charles, House |
| Treadwell, William, House |
| Triangle Ranch Headquarters Historic District |
| Trinity Episcopal Church |
| Trinity Episcopal Church |
| Trinity Evangelical Church |
| Trinity Evangelical Lutheran Church Complex |
| Trinity United Methodist Church |
| Tromble House |
| Trowbridge, Charles, House |
| Truck Line Bridge No. 1 |
Data from United States Park Service and Wikidata
