Michigan - Area of significance: Commerce
| Saginaw City Historic Business District |
| Saginaw River Light Station |
| Saint Louis Downtown Historic District |
| Sault Ste. Marie Historic Commercial District |
| Savings Bank Building |
| Schuyler Mill-Ford Soybean Plant Complex |
| Seul Choix Pointe Light Station |
| Sexton, William K. and Nellie, House |
| Shelden-Dee Block |
| Shelden, Ransom B., House |
| Sibley, Frederic M., Lumber Company Office Building |
| Silliman, Arthur, House |
| Skillagalee Light Station |
| Sleeping Bear Inn |
| Sleeping Bear Point Life Saving Station |
| Smith-Turner House |
| South Jefferson Avenue Historic District |
| South Michigan Avenue Historic District |
| Sprague, Rollin, Building-Old Stone Store |
| S.S. VALLEY CAMP |
| Stafford, Frederick H. and Elizabeth, House |
| State Savings Bank |
| St. Clair River Tunnel |
| Stearns, Frederick, Building |
| Stimpson, Forrest J., House |
| St. John's Episcopal Church |
| St. Josaphat's Roman Catholic Church Complex |
| St. Joseph North Pier Inner and Outer Lights |
| St. Martin Island Light Station |
| St. Mary's Falls Canal |
| Stuart Area Historic District |
| Stuart, Robert, House |
| Stuber-Stone Building |
| Sturgeon Point Light Station |
| Superior Street Commercial Historic District |
| Tawas Point Light Station |
| Tecumseh Downtown Historic District |
| Temple, Samuel W., House |
| Thunder Bay Island Light Station |
| Todd, Edwin, House |
| Tomlinson, Samuel J., House |
| Trowbridge, Charles, House |
| Union Block |
| Union Block |
| Union Meat Market |
| Upjohn Company Office Building |
| Upper Peninsula Brewing Company Building |
| Van Ornum's Addition Historic District |
| Vaughn’s Book Store |
| Vermont House and Fenton Grain Elevator |
| Vicksburg Historic District |
| Vinton Building |
| Virginia Park Historic District |
| Vivian, Jr., J., and Company Building |
| Wagner's Block |
| Wallace Block-Old Saline Village Hall |
| Wall-Seppanen House |
| Wardell, The |
| Watrous General Store |
| Watson, William H. and Sabrina, House |
| Wayland Downtown Historic District |
| Weinmann Block |
| Western House |
| West Pearl Street Historic District |
| West Saint Clair Street Historic District |
| West Side Historic Residential District |
| Westside Neighborhood Historic District |
| West Town Historic Commercial and Industrial District |
| West Vernor-Junction Historic District |
| West Vernor-Lawndale Historic District |
| West Vernor-Springwells Historic District |
| Whaley, Robert J., House |
| Whitcomb Hotel |
| White, Jay, House |
| White Shoal Light Station |
| Whitney, David, House |
| Whitney Tavern Stand |
| Williamston Downtown Historic District |
| Willis-Selden Historic District |
| Wilson Barn |
| Wing-Allore House |
| Winsor and Snover Bank Building |
| Winter Inn |
| Wright, Ammi and William, House |
| Wright Opera house Block Complex |
Data from United States Park Service and Wikidata
