Kentucky - Area of significance: Commerce
| Schuster Building |
| Scotland |
| Scottsville Downtown Commercial Historic District |
| Second and Market Streets Historic District |
| Seeley, Edward B., House |
| Selema Hall |
| Seventh Street Historic District |
| Shelby County Courthouse and Main Street Commercial District |
| Shinkle, Amos, Summer Residence |
| Smith, F. A., House |
| Smith House |
| Smith, Maj. Hampden, House |
| Smith, Thomas, House |
| South Courthouse Square Historic District |
| South Union Shakertown Historic District |
| Springfield Historic Commercial District |
| Spur Gasoline Station |
| Stacey Hotel |
| Stanford Commercial District |
| Stearns Administrative and Commercial District |
| Stewart, Dr. Edward S., House |
| Stewart's Dry Goods Company Building |
| Stitzel, Arthur P., House |
| Tatham Springs |
| Taylor, J. B., and Son Feed Store |
| The KFC White House Building |
| The Wolke House |
| Third and Jefferson Streets Historic District |
| Third and Market Streets Historic District |
| Thomas, Samuel B., House |
| Todd-Montgomery Houses |
| Tompkins-Buchanan House |
| Tonieville Store |
| Trotter's Warehouse |
| Tuliphurst |
| Turner, J.L. and Son, Building |
| Tyler-Muldoon House |
| Undulata |
| U.S. Army Corps of Engineers Superintendent's House and Workmen's Office |
| Victorian Commercial Block |
| Vine Grove Historic District |
| Waddy Bank Building |
| Walden Place |
| Walker House |
| Walker House |
| Wallace Station Historic District |
| Wallace Woods Area Residential Historic District |
| Washington Historic District |
| Water Street Historic District |
| Watson Store |
| Weisenberger Mills and Related Buildings |
| Weissinger-Gaulbert Apartments |
| West Fourth Street District |
| West Main Street Historic District |
| West Main Street Historic District |
| West Point Hotel |
| West Side-Main Strasse Historic District |
| Whiskey Row Historic District |
| Whitesburg Historic District |
| Whiteside Bakery |
| Widman's Saloon and Grocery |
| Wiedemann, Charles, House |
| Willisburg Central Bank and Post Office |
| Wilson Motel |
| Wilson, William, House |
| Winchester Downtown Commercial District |
| Woolworth, F.W., Building |
| Yeager General Store |
| Young, James, House and Inn |
| Young's Ferry House |
Data from United States Park Service and Wikidata
