Kentucky - Area of significance: Architecture
| Smith, Dr. William Addison, House |
| Smith, Enoch, House |
| Smith, F. A., House |
| Smith, George and Nellie White, House |
| Smith, George W., House |
| Smith House |
| Smith House |
| Smith House |
| Smith, James, Tanyard |
| Smith, Levi J., House |
| Smith, Maj. Hampden, House |
| Smith, Mitchell Baker, Company Building |
| Smith, Nelson and Clifton Rodes, House |
| Smiths Grove Baptist Church |
| Smiths Grove District |
| Smiths Grove Presbyterian Church |
| Smith, Thomas, House |
| Smith, William Alexander, House |
| Smith-Williams House |
| Smokehouse on Riverside Creek |
| Snapp House |
| Snead Manufacturing Building |
| Snell, Perry, Hall |
| Snook House |
| Snook, Van B., House |
| Snow Hill |
| Soldiers and Sailors Memorial Gymnasium |
| Soldiers Retreat |
| Somerset City School and Carnegie Library |
| Somerset Downtown Commercial District |
| Sousley, Franklin R., Birthplace |
| South Central Bell Company Office Building |
| South Cherry Street Historic District |
| South Courthouse Square Historic District |
| Southeast Lexington Residential and Commercial District |
| Souther, Abe, House |
| Southern Heights-Beechmont District |
| Southern National Bank |
| Southern Railway Passenger Depot |
| South Frankfort Neighborhood Historic District |
| Southgate House |
| Southgate-Parker-Maddux House |
| South Greenup District |
| South Hill Historic District |
| South Louisville Reformed Church |
| South Main and South Elm Streets Historic District |
| South Main Street Historic District |
| South Union Shaker Center House and Preservatory |
| South Union Shakertown Historic District |
| Southwest Glasgow Residential District |
| Spalding Hall, St. Joseph's College |
| Spalding, Leonard A., House |
| Spears-Craig House |
| Spears, Jacob, Distillery |
| Spears, Jacob, House |
| Speed Building |
| Speed Hall |
| Springfield Armory |
| Springfield Baptist Church |
| Springfield Graded School |
| Springfield Historic Commercial District |
| Spring Garden-John Leavell |
| Springhill |
| Spring Hill |
| Spring Hill Farm |
| Spring Hill (Thomas Lillard House) |
| Spring House at Flat Fork |
| Springhouse in Mays Lick |
| Spring Station |
| Spur Gasoline Station |
| Stader Hotel |
| Stadium |
| Stafford, Francis M., House |
| St. Aloysius Church |
| Stambaugh Church of Christ |
| Stambaugh House |
| Stanford Commercial District |
| Stansbury, Zack, House |
| St. Anthony's Roman Catholic Church, Rectory, Convent, and School |
| Stapp Homeplace |
| Stark House |
| Starks Building |
| State Theatre |
| St. Augustine Catholic Church |
| St.Bonifacius Kirche Complex |
| St. Catherine of Sienna Convent |
| St. Cecilia School Building |
| St. Dominic's Catholic Church |
| Steam Engine Company No. 10 |
| Steam Engine Company No. 11 |
| Steam Engine Company No. 18 |
| Steam Engine Company No. 2 |
| Steam Engine Company No. 20 |
| Steam Engine Company No. 20 |
| Steam Engine Company No. 21 |
| Steam Engine Company No. 22 |
| Steam Engine Company No. 3 |
| Steam Engine Company No. 4 |
| Steam Engine Company No.4 |
| Steam Engine Company No. 7 |
Data from United States Park Service and Wikidata