Indiana - Significance region: Local
| East Shore Historic District |
| East Spring Street Historic District |
| East Wabash Historic District |
| East Washington Street Historic District |
| East Washington Street Historic District |
| Eckhart Public Library and Park |
| Edinburgh Commercial Historic District |
| Edna Collings Covered Bridge |
| Edsall, William S., House |
| Edward's Ford Bridge |
| Egan, Maurice, House |
| Ehrmann Building |
| Elder-Pyle House |
| Eliason Farm |
| Elkhart County Courthouse |
| Elkhart Downtown Commercial Historic District |
| Ellerbusch Archeological Site (12W56) |
| Eller-Hosford House |
| Ellettsville Downtown Historic District |
| Elliott, James, Farm |
| Ellis-Schindler House |
| Ellsworth Historic District |
| Elm Spring Farm |
| Elston, Col. Isaac C., House |
| Elston Grove Historic District |
| Elston Grove Historic District |
| Elwood Downtown Historic District |
| Ely, Homestead |
| Emelie |
| Emerson Avenue Addition Historic District |
| Emerson Heights Historic District |
| Emerson, Ralph Waldo, School |
| Engine House No. 23 |
| Engine House No. 3 |
| Enterprise Hotel |
| Epsilon II Archeological Site (12MO133) |
| Erwin House |
| Eskilson Historic District |
| Esplanade Apartments |
| Evangelische Lutherische Emanuels Kirche |
| Evans Lustron House |
| Evansville Brewing Company |
| Evansville College |
| Evansville Downtown Historic District |
| Evansville Furniture Exchange-Court Building |
| Evansville Journal News |
| Evansville Municipal Market |
| Evergreen Hill |
| Ewbank, Lancelot C., House |
| Fairfield Manor |
| Fairmount Commercial Historic District |
| Faith, Thomas, House |
| Fall Creek Meeting House |
| Falley Home |
| Fame Laundry |
| F. & A.M. Tuscan Lodge No. 143 |
| Farmers Club |
| Farmers Institute |
| Farmers Security Bank |
| Farmland Downtown Historic District |
| Farnham, Erastus and Louise, House and Barn |
| Fawn River State Fish Hatchery |
| Fayette County Courthouse |
| Federal Building |
| Federal Building |
| Feeder Dam Bridge |
| Fellwock Garage |
| Felt's Farm |
| Ferdinand Historic District |
| Ferguson, Benjamin, House |
| Ferguson House |
| Feustel, Robert M., House |
| Fidelity Trust Building |
| Fine, M. and Sons Building |
| Finney, Joseph, House |
| Fire House No. 3 |
| Fire House No. 7 |
| Fire Station No. 1 |
| Fire Station No. 9 |
| Firestone Tire and Rubber Store |
| First Baptist Church |
| First Baptist Church |
| First Christian Church |
| First Congregational Church |
| First Congregational Church of Michigan City |
| First Evangelical United Church of Christ |
| First National Bank |
| First Presbyterian Church |
| First Presbyterian Church |
| First Presbyterian Church |
| First Presbyterian Church |
| First Unitarian Church of Hobart |
| Flanner House Homes |
| Fletcher, Calvin I., House |
| Fletcher Place Historic District |
| Ford Motor Company Indianapolis Assembly Plant |
| Forebears |
| Foreman-Case House |
| Forest Hill Cemetery |
| Forest Hills Country Club |
Data from United States Park Service and Wikidata
