Indiana - Significance region: Local
| Southmoor Apartment Hotel |
| Southport High School, Old |
| South Side Turnverein Hall |
| South Walnut Street Historic District |
| South Wayne Historic District |
| South Whitley Historic District |
| Speakman-Miller-Kittle Farm |
| Spencer County Courthouse |
| Spencer Courthouse Square Historic District |
| Spencer Presbyterian Church and Manse |
| Spencer Public Library |
| Spencer Town Hall and Fire Station |
| Spencerville Covered Bridge |
| Spink |
| Spink Arms Hotel |
| Spring Street Freight House |
| Spring Vale Cemetery |
| St. Adalbert Church Complex |
| Stahly-Nissley-Kuhns Farm |
| Stallbohm Barn-Kaske House |
| Star Building |
| Starke County Bridge No. 39 |
| Starke County Courthouse |
| Starkweather's, Samuel, Lime Kiln and Quarry |
| Star Milling and Electric Company Historic District |
| State and Prospect District |
| State Bank of Hammond Building |
| State Normal Library |
| State Street-Division Street Historic District |
| State Street Historic District |
| St. Augustine's Episcopal Church |
| St. Boniface Church |
| St. Casimir Parish Historic District |
| Steele Dunning Historic District |
| Stephenson, Joseph W. and Edith M., House |
| Stephenson Underwear Mill |
| Steuben County Courthouse |
| Steuben County Jail |
| Stevens, Levi, House |
| Stewart Manor (Charles B. Sommers House) |
| Stewart-Studebaker House |
| St. Ferdinand Parish Historic District |
| St. George Lutheran Church |
| Stidham United Methodist Church |
| Stinesville Commercial Historic District |
| Stinesville Historic District |
| Stipp-Bender Farm |
| St. James Memorial Chapel |
| St. John of the Cross Episcopal Church, Rectory and Cemetery |
| St. John's Church and Rectory |
| St. John's Episcopal Church |
| St. John's Evangelical Protestant Church |
| St. John's Lutheran Church |
| St. John's Lutheran Church and School |
| St. John's Lutheran Church and School |
| St. Joseph Catholic Church |
| St. Joseph County Infirmary |
| St. Joseph Neighborhood Historic District |
| St. Joseph School |
| St. Joseph’s Parish Square |
| St. Louis, Besancon, Historic District |
| St. Luke's Episcopal Church |
| St. Mary Historic District |
| St. Mary's Catholic Church |
| Stockdale Mill |
| Stockheughter Covered Bridge |
| Stonebraker, John & Caroline, House |
| Stone, Judge Earl S., House |
| Stoner, Lycurgus, House |
| Stone's Trace |
| Story Historic District |
| St. Patrick's Farm |
| St. Patrick's Roman Catholic Church |
| St. Paul Methodist Episcopal Church |
| St. Peter's Square |
| St. Philip Neri Parish Historic District |
| Straber Ford Bridge |
| Straus, Jacob, House |
| St. Rose de Lima Roman Catholic Church and Rectory |
| Strunz, Christian G., House |
| St. Stephen's African Methodist Episcopal Church |
| Studebaker Clubhouse and Tree Sign |
| Stultz-Stanley House |
| Stumpf, George, House |
| Sturm, Louis H., Hardware Store |
| Stutz Motor Car Company Factory |
| St. Vincent Villa Historic District |
| Sugar Grove Meetinghouse and Cemetery |
| Sullivan County Courthouse |
| Sullivan County Poor Home |
| Sullivan Courthouse Square Historic District |
| Sults-Quivey-Hartman Polygonal Barn and Farm |
| Summers-Longley House-Building |
| Sunken Gardens |
| Sunset Park Pavilion |
| Swayzee, Aaron, House |
| Swedish Evangelical Lutheran Carmel Chapel and Carmel Cemetery |
| Sweeton, Charles, House |
| Swinney, Thomas W., House |
| Sycamore Row |
Data from United States Park Service and Wikidata
