Indiana - Area of significance: Commerce
| Russellville Historic District |
| Salem Downtown Historic District |
| Savoy |
| Schlemmer, Otto, Building |
| Schnull-Rauch House |
| Scotland Hotel |
| Scott, Andrew F., House |
| Scottsburg Courthouse Square Historic District |
| Second St. Joseph Hotel |
| Selig's Dry Goods Company Building |
| Seller's Standard Station and Pullman Diner |
| Seymour Commercial Historic District |
| Shelbyville Commercial Historic District |
| Shelton |
| Sheridan Downtown Commercial Historic District |
| Shirk, W. W., Building |
| Shoals Historic District |
| Sid-Mar |
| Siegel's Department Store |
| Sigler, Eli, House |
| Silver Lake Historic District |
| Skinner, DeForest, House |
| Smith, Everel S., House |
| Smith, Robert, Mortuary |
| Soldiers and Sailors Memorial Coliseum |
| South Michigan Street Historic District |
| Southmoor Apartment Hotel |
| South Whitley Historic District |
| Spencer Courthouse Square Historic District |
| Spink |
| Spring Street Freight House |
| Starr Historic District |
| State and Prospect District |
| State Bank of Hammond Building |
| State Bank of Indiana, Branch of (Memorial Hall) |
| State Street Historic District |
| Stewart-Studebaker House |
| Stinesville Commercial Historic District |
| Stinesville Historic District |
| Stockdale Mill |
| Story Historic District |
| Straus, Jacob, House |
| Sturm, Louis H., Hardware Store |
| Sullivan Courthouse Square Historic District |
| Sylvania |
| Taggart, F.P., Store |
| Taylor Carpet Company Building |
| Teague Barn Wabash Importing Company Farm Stable |
| Twelve Points Historic District |
| Union City Commercial Historic District |
| Upper Main Street Historic District |
| Valparaiso Downtown Commercial District |
| Vermilyea Inn Historic District |
| Versailles Courthouse Square Historic District |
| Vevay Historic District |
| Vienna |
| Vincennes Historic District |
| Virginia Avenue District |
| Wabash Avenue-East Historic District |
| Wabash Avenue-West Historic District |
| Walker, Madame C. J., Building |
| Walkerton Historic District |
| Walnut Street Historic District |
| Warren Downtown Historic District |
| Warsaw Courthouse Square Historic District |
| Washington Commercial Historic District |
| Washington Street-Monument Circle Historic District |
| Welborn Historic District |
| Welborn-Ross House |
| West Baden National Bank |
| West Central Historic District |
| West Eighth Street Historic District |
| West End Historic District |
| Westfield Historic District |
| West Washington Historic District |
| Whitewater Canal Historic District |
| Wil-Fra-Mar |
| Williams, Samuel P., House |
| Wilson |
| Wilson, J. Woodrow, House |
| Winchester Courthouse Square Historic District |
| Wood, John, Old Mill |
| Woolery Stone Company |
| Wright, Thomas T., House |
| Wyndham |
Data from United States Park Service and Wikidata
