Indiana - Area of significance: Architecture
| Saint John's Episcopal Church |
| Saint Joseph's Nurses Home |
| Saint Mary-of-the-Woods Historic District |
| Saint Paul's Evangelical Lutheran Church |
| Salem Downtown Historic District |
| Salem Methodist Episcopal Church |
| Salem's Baptist Church |
| Savoy |
| Schaeffer, Michael, House |
| Schenck, Benjamin, Mansion |
| Schlemmer, Otto, Building |
| Schmitz Block |
| Schnull-Rauch House |
| Scholle, Mattias, House |
| Schwietermann Hall |
| Scott, Andrew F., House |
| Scottish Rite Cathedral |
| Scott-Lucas House |
| Scott-Rumley House |
| Scottsburg Courthouse Square Historic District |
| Scott Street Pavilion |
| Scudder, Dr. John A., House |
| Second Baptist Church |
| Second St. Joseph Hotel |
| Secrest-Wampler House |
| Seiberling Mansion |
| Selig's Dry Goods Company Building |
| Seller's Standard Station and Pullman Diner |
| Senour, Frank, Round Barn |
| Service, Jeremiah H., House |
| Seville, The |
| Sewell, William C. B., House |
| Seybold, George, House |
| Seymour Commercial Historic District |
| Shadowwood |
| Shafer, Joseph, Farm |
| Shakamak State Park Historic District |
| Sharp, Mathias, House |
| Shawnee Place Historic District |
| Sheffield Inn |
| Shelburn Interurban Depot-THI&E Interurban Depot |
| Shelby County Courthouse |
| Shelby Place Historic District |
| Shelbyville Commercial Historic District |
| Shelbyville High School |
| Shelton |
| Sheridan Downtown Commercial Historic District |
| Sherman Building |
| Shindler-Stetson House |
| Shirk-Edwards House |
| Shirk, W. W., Building |
| Shoals Historic District |
| Shortridge-Meridian Street Apartments Historic District |
| Shrewsbury, Charles L., House |
| Shull, Henry, Farmhouse Inn |
| Sid-Mar |
| Siegel's Department Store |
| Sigler, Eli, House |
| Silver Lake Historic District |
| Simonson, Alfred, House |
| Simpson-Breedlove House |
| Simpson Memorial United Methodist Church |
| Simpson Nursery Historic District |
| Skinner, DeForest, House |
| Smith, Everel S., House |
| Smith Field |
| Smith, Henry W., House |
| Smith, John W., House |
| Smith, Robert, Mortuary |
| Smith, Samuel G., Farm |
| Soldiers and Sailors Memorial Coliseum |
| Solomon Enclave |
| Sommer, August, House |
| Sommerer House |
| Sons of Israel Synagogue |
| Souder, Dr. Christopher, House |
| South 9th Street Historic District |
| South Bend City Cemetery |
| South Bend Remedy Company |
| South Bend Remedy Company Building |
| South Delphi Historic District |
| South Frankfort Historic District |
| South Grade School Building |
| South Milford I.O.O.F. Hall |
| Southmoor Apartment Hotel |
| Southport High School, Old |
| South Side Turnverein Hall |
| South Walnut Street Historic District |
| South Wayne Historic District |
| South Whitley Historic District |
| Southwood Park Historic District |
| Speakman-Miller-Kittle Farm |
| Spencer County Courthouse |
| Spencer Courthouse Square Historic District |
| Spencer Presbyterian Church and Manse |
| Spencer Public Library |
| Spencer Town Hall and Fire Station |
| Spencerville Covered Bridge |
| Spink |
| Spink Arms Hotel |
Data from United States Park Service and Wikidata
