Florida - Significance region: National
| African Cemetery at Higgs Beach |
| AFRICAN QUEEN |
| Airport Clear Zone Archeological Site |
| Alcazar Hotel |
| Allen, Hervey, Study |
| Angustias Shipwreck Site |
| Armory, The |
| Avero House |
| Bailey, Maj. James B., House |
| Barracks and Mess Building-US Coast Guard Air Station at Dinner Key |
| Barrancas National Cemetery |
| Bellevue |
| Benjamin, Judah P., Memorial |
| Bethune, Mary McLeod, Home |
| Big Mound Key-Boggess Ridge Archeological District |
| Blanchette Archeological Site |
| Bok Mountain Lake Sanctuary and Singing Tower |
| Brokaw-McDougall House |
| Bulow Plantation Ruins |
| Cape Canaveral Air Force Station |
| Cape Florida Lighthouse |
| Caples'-Ringlings' Estates Historic District |
| Cascades Park |
| Castillo de San Marcos National Monument |
| Cathedral of St. Augustine |
| Cayson Mound and Village Site |
| Central Instrumentation Facility |
| Chautauqua Hall of Brotherhood |
| Chaves Shipwreck Site |
| City Island Ball Park |
| Cockroach Key |
| Constitution Obelisk |
| Crawlerway |
| Crystal River Indian Mounds |
| Dade Battlefield Historic Memorial |
| Demere Key |
| DeSoto National Memorial |
| Donnelly House |
| DUCHESS (Sponge Hooking Boat) |
| Eatonville Historic District |
| El Centro Espanol de Tampa |
| El Gallo Indiano Shipwreck Site |
| El Infante Shipwreck Site |
| El Rubi Shipwreck Site |
| Ely-Criglar House |
| Emanuel Point Shipwreck Site |
| Escambe |
| Fairbanks House |
| First Presbyterian Church Archeological Site |
| Flagler, Henry Morrison, House; Whitehall |
| Florida Southern College Architectural District |
| Fort Caroline National Memorial |
| Fort Clinch |
| Fort Desoto Batteries |
| Fort Foster |
| Fort Gadsden Historic Memorial |
| Fort Jefferson National Monument |
| Fort King Site |
| Fort Matanzas National Monument |
| Fort Mose Site, Second |
| Fort Pickens |
| Fort San Marcos de Apalache |
| Fort Walton Mound |
| Fort Zachary Taylor |
| Freedom Tower |
| Galt Island Archeological District |
| GEORGE N. CRETEKOS (Sponge Diving Boat) |
| Gonzalez-Alvarez House |
| GOVERNOR STONE (schooner) |
| Grace United Methodist Church |
| Grange Archeological Site |
| Great Oaks |
| HA. 19 (Japanese Midget Submarine) |
| HALF MOON (shipwreck) |
| Hawks Archeological Site |
| Headquarters Building |
| Hemingway, Ernest, House |
| Herrara Shipwreck Site |
| Hialeah Park Race Track |
| Hillsboro Inlet Light Station |
| Hotel Ponce De Leon |
| Hurston, Zora Neale, House |
| Indian Key |
| INGHAM (USCGC) |
| Janet's Archeological Site |
| John Pennekamp Coral Reef State Park and Reserve |
| Josslyn Island Site |
| Kampong |
| Kerouac, Jack, House |
| Key West Historic District |
| Kingsley Plantation |
| Lake Jackson Mounds |
| Lake Pithlachocco Canoe Site |
| Launch Complex 39 |
| Launch Complex 39-Pad A |
| Launch Complex 39-Pad B |
| Launch Control Center |
| Lavalle House |
| Lewis Mausoleum |
| Lindsley House |
Data from United States Park Service and Wikidata
