Florida - Area of significance: Architecture
| Seybold Baking Company Factory |
| Shady Grove Primitive Baptist Church |
| Shelfer, E. B., House |
| Shell Hammock Landing |
| Sherman Arcade |
| Shoreland Arcade |
| Sikes House |
| Silver Springs |
| Sinclair Service Station |
| Singleton, Micajah T., House |
| Smith, Dr. Chandler Holmes, House |
| Smith, E. C., House |
| Smith, H. W., Building |
| Smoky Hollow Historic District |
| Sneads Community House and Old Pump |
| Snell Arcade |
| Snyder Memorial Methodist Episcopal Church |
| Solla-Carcaba Cigar Factory |
| Sollner-Wall House |
| Sopchoppy High School Gymnasium, Old |
| Sopchoppy School |
| Souder, Paul M., House |
| South Bartow Residential District |
| South Beach Street Historic District |
| South Brooksville Avenue Historic District |
| Southeast Gainesville Residential District |
| South Jacksonville Grammar School |
| South Lake Morton Historic District |
| South Peninsula Historic District |
| South Ridgewood Elementary School |
| South River Drive Historic District |
| Southside School |
| South Side School |
| South Ward School |
| Southwest Daytona Beach Black Heritage District |
| Southwick-Harmon House |
| Spanish Apartments |
| Spanish Coquina Quarries |
| Spell House |
| Springfield Historic District |
| Spring Lake Community Center |
| SS COPENHAGEN (shipwreck) |
| S & S Sandwich Shop |
| St. Anastasia Catholic School, Old |
| Stanbury Cottage |
| Standard Oil Service Station |
| St. Andrew School |
| St. Andrew's Episcopal Church |
| St. Andrews Episcopal Church |
| St. Anthony School |
| Stanton, Edwin M., School |
| St. Augustine Civic Center |
| St. Augustine Lighthouse and Keeper's Quarters |
| St. Augustine Town Plan Historic District |
| St. Augustine Water Works |
| St. Cloud Downtown Historic District |
| Stephens House |
| Stetson, John B., House |
| Stetson University Campus Historic District |
| Stevens, Ann, House |
| St. Gabriel's Episcopal Church |
| St. George Episcopal Church |
| St. James A. M. E. Church |
| St. James Building |
| St. John's Baptist Church |
| St. John's Episcopal Church |
| St. Johns Light |
| St. John's Lighthouse |
| St. Joseph Catholic Mission Church |
| St. Joseph's Catholic Church |
| St Leo Abbey Historic District |
| St. Lucie High School |
| St. Luke Baptist Church |
| St. Luke's Episcopal Church and Cemetery, Old |
| St. Margaret's Episcopal Church and Cemetery |
| St. Mark's Episcopal Church |
| St. Mary Catholic Church |
| St. Mary's Church |
| St. Mary's Episcopal Church |
| St. Mary's Episcopal Church and Rectory |
| St. Matthews Methodist Episcopal Church |
| St. Michael's Creole Benevolent Association Hall |
| ST. NICHOLAS III (Sponge Diving Boat) |
| ST. NICHOLAS VI (Sponge Diving Boat) |
| Stockton-Curry House |
| Stockton-Lindquist House |
| Stovall House |
| St. Paul Lutheran Church |
| St. Petersburg Public Library |
| St. Petersburg Woman's Club |
| Strickland-Herold House |
| Strickland School |
| St. Rita's Colored Catholic Mission |
| Studebaker Building |
| Sun Bright |
| Sundy, John and Elizabeth Shaw, House |
| Sunrise Theatre |
| Sunset Hotel |
| Sunshine State Arch |
| Surveyor's Lake Schoolhouse |
Data from United States Park Service and Wikidata
